PKG1α oxidation negatively regulates food seeking behaviour and reward

• Published in: Redox biology Vol. 21; p. 101077
• Main Authors: Duraffourd, Celine, Huckstepp, Robert T R, Braren, Ingke, Fernandes, Cathy, Brock, Olivier, Delogu, Alessio, Prysyazhna, Oleksandra, Burgoyne, Joseph, Eaton, Philip
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier 01.02.2019
• Subjects: Animals; Behavior, Animal; Cyclic GMP-Dependent Protein Kinase Type I - metabolism; Disulfides - metabolism; Dopamine - metabolism; Dopamine - pharmacology; Enzyme Activation - drug effects; Feeding Behavior; Female; Levodopa - metabolism; Levodopa - pharmacology; Male; Mice; Mice, Knockout; Monoamine Oxidase - metabolism; Nitric Oxide - metabolism; Oxidation-Reduction; Protein Processing, Post-Translational; Research Paper; Reward; Ventral Tegmental Area - drug effects; Ventral Tegmental Area - metabolism; Reward; Ventral Tegmental Area; Food-seeking behaviour; PKG1α

Genes that are highly conserved in food seeking behaviour, such as protein kinase G (PKG), are of interest because of their potential role in the global obesity epidemic. PKG1α can be activated by binding of cyclic guanosine monophosphate (cGMP) or oxidant-induced interprotein disulfide bond formati...