Epigenetic Modifications of the α-Synuclein Gene and Relative Protein Content Are Affected by Ageing and Physical Exercise in Blood from Healthy Subjects

• Published in: Oxidative medicine and cellular longevity Vol. 2018; no. 2018; pp. 1 - 16
• Main Authors: Martini, Claudia, Franzoni, Ferdinando, Trincavelli, Maria Letizia, Iofrida, Caterina, Giacomelli, Chiara, Pietrobono, Deborah, Costa, Barbara, Daniele, Simona, Fusi, Jonathan
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018; Hindawi; John Wiley & Sons, Inc
• Subjects: DNA methylation; Epigenetics; Exercise; Neurosciences; Parkinson's disease

Epigenetic regulation may contribute to the beneficial effects of physical activity against age-related neurodegeneration. For example, epigenetic alterations of the gene encoding for α-synuclein (SNCA) have been widely explored in both brain and peripheral tissues of Parkinson’s disease samples. Ho...