Phosphorylation of Mineralocorticoid Receptor Ligand Binding Domain Impairs Receptor Activation and Has a Dominant Negative Effect over Non-phosphorylated Receptors - Jiménez-Canino, Rubén; Fernandes, Miguel X.; de la Rosa, Diego Alvarez (The Journal of biological chemistry, 2016)
Keywords: Active Transport, Cell Nucleus - drug effects; Active Transport, Cell Nucleus - genetics; aldosterone; Amino Acid Substitution; Animals; Cell Biology; Cell Nucleus - genetics; Cell Nucleus - metabolism; Chlorocebus aethiops; cortisol; COS Cells; gene transcription; glucocorticoid receptor; Humans; kidney; Mice; mineralocorticoid receptor; Mutation, Missense; Phosphorylation; Protein Binding; Receptors, Mineralocorticoid - agonists; Receptors, Mineralocorticoid - chemistry; Receptors, Mineralocorticoid - genetics; Receptors, Mineralocorticoid - metabolism; steroid hormone receptor; Transcriptional Activation - drug effects; Transcriptional Activation - physiology; kidney; cortisol; gene transcription; glucocorticoid receptor; aldosterone; mineralocorticoid receptor; steroid hormone receptor; phosphorylation