The Effects of Intraperitoneal Pentoxifylline Treatment in Rat Pups With Hypoxic-Ischemic Encephalopathy

• Published in: Pediatric neurology Vol. 49; no. 5; pp. 319 - 323
• Main Authors: Kalay, Salih, MD, Oztekin, Osman, MD, Tezel, Gonul, MD, Aldemir, Hakan, MD, Sahin, Emel, PhD, Koksoy, Sadi, MD, Akcakus, Mustafa, MD, Oygur, Nihal, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2013
• Subjects: Animals; Animals, Newborn; Brain - drug effects; Brain - metabolism; Caspase 3 - genetics; Caspase 3 - metabolism; caspase-3; cytokine; Disease Models, Animal; Female; Gene Expression Regulation - drug effects; Hypoxia-Ischemia, Brain - complications; Hypoxia-Ischemia, Brain - drug therapy; Hypoxia-Ischemia, Brain - pathology; hypoxic ischemic encephalopathy; Injections, Intraperitoneal; Interleukin-1beta - genetics; Interleukin-1beta - metabolism; Male; Neurology; Pediatrics; pentoxifylline; Pentoxifylline - administration & dosage; Platelet Aggregation Inhibitors - therapeutic use; Rats; Rats, Wistar; RNA, Messenger - metabolism; Statistics, Nonparametric; Time Factors; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; cytokine; pentoxifylline; hypoxic ischemic encephalopathy; caspase-3

Abstract Background The aim of this study was to evaluate the effects of postischemic treatment with pentoxifylline on the cytokine gene expressions and neuronal apoptosis in neonatal rat model of hypoxic-ischemic encephalopathy. Methods Seven-day-old Wistar rat pups (n = 40) of either sex, delivere...