Systems-wide proteomic characterization of combinatorial post-translational modification patterns

Protein post-translational modifications (PTMs) have been widely shown to influence protein-protein interactions, direct subcellular location and transduce a variety of both internal and externally generated signals into cellular/phenotypic outcomes. Mass spectrometry has been a key tool for the elu...

Full description

Saved in:
Bibliographic Details
Published inExpert review of proteomics Vol. 7; no. 1; pp. 79 - 92
Main Authors Young, Nicolas L, Plazas-Mayorca, Mariana D, Garcia, Benjamin A
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.02.2010
Expert Reviews Ltd
Informa Healthcare
Subjects
electron-capture dissociation
electron-transfer dissociation
histone code
Mass spectrometry
Mass Spectrometry - methods
Methods
middle-down approach
Observations
Post-translational modification
Properties
Protein Processing, Post-Translational
Proteins - analysis
Proteomics
Proteomics - methods
top-down approach
United States
Online AccessGet full text

Cover

Abstract Protein post-translational modifications (PTMs) have been widely shown to influence protein-protein interactions, direct subcellular location and transduce a variety of both internal and externally generated signals into cellular/phenotypic outcomes. Mass spectrometry has been a key tool for the elucidation of several types of PTMs in both qualitative and quantitative manners. As large datasets on the proteome-wide level are now being generated on a daily basis, the identification of combinatorial PTM patterns has become feasible. A survey of the recent literature in this area shows that many proteins undergo multiple modifications and that sequential or hierarchal patterns exist on many proteins; the biology of these modification patterns is only starting to be unraveled. This review will outline combinatorial PTM examples in biology, and the mass spectrometry-based techniques and applications utilized in the investigations of these combinatorial PTMs.
AbstractList Protein post-translational modifications (PTMs) have been widely shown to influence protein-âprotein interactions, direct subcellular location and transduce a variety of both internal and externally generated signals into cellular/phenotypic outcomes. Mass spectrometry has been a key tool for the elucidation of several types of PTMs in both qualitative and quantitative manners. As large datasets on the proteome-wide level are now being generated on a daily basis, the identification of combinatorial PTM patterns has become feasible. A survey of the recent literature in this area shows that many proteins undergo multiple modifications and that sequential or hierarchal patterns exist on many proteins; the biology of these modification patterns is only starting to be unraveled. This review will outline combinatorial PTM examples in biology, and the mass spectrometry-based techniques and applications utilized in the investigations of these combinatorial PTMs.
Protein post-translational modifications (PTMs) have been widely shown to influence protein-protein interactions, direct subcellular location and transduce a variety of both internal and externally generated signals into cellular/phenotypic outcomes. Mass spectrometry has been a key tool for the elucidation of several types of PTMs in both qualitative and quantitative manners. As large datasets on the proteome-wide level are now being generated on a daily basis, the identification of combinatorial PTM patterns has become feasible. A survey of the recent literature in this area shows that many proteins undergo multiple modifications and that sequential or hierarchal patterns exist on many proteins; the biology of these modification patterns is only starting to be unraveled. This review will outline combinatorial PTM examples in biology, and the mass spectrometry-based techniques and applications utilized in the investigations of these combinatorial PTMs.
Audience Academic
Author Plazas-Mayorca, Mariana D
Garcia, Benjamin A
Young, Nicolas L
Author_xml – sequence: 1
  givenname: Nicolas L
  surname: Young
  fullname: Young, Nicolas L
– sequence: 2
  givenname: Mariana D
  surname: Plazas-Mayorca
  fullname: Plazas-Mayorca, Mariana D
– sequence: 3
  givenname: Benjamin A
  surname: Garcia
  fullname: Garcia, Benjamin A
BackLink https://www.ncbi.nlm.nih.gov/pubmed/20121478$$D View this record in MEDLINE/PubMed
BookMark eNptkc1q3TAQhUVJaX43fYBimkWh4BvJkix7GULaBgJdJFkLWR61CrblSrqEm6fPuE4LCUELSaPvjGbmHJK9KUxAyEdGN0w29RnMcUPbDaP0HTlgSoiy4Y3aw7NQTdkKSffJYUr3lHLRyvoD2a8oq5bHA2JudinDmMoH30Mxx5AhjN4W9reJxmaI_tFkH6YiuMKGsfOTySF6MxRzSLnM0Uxp-EtgaAy9d96ugtlklE_pmLx3Zkhw8rwfkbtvl7cXP8rrn9-vLs6vSysUy6VkjeWcqbpRhlHZdk7SVlTQQW2lslZ0qhdOygprb1jdCGqVUBIbVVIAVPyIfFnzYhN_tpCyHn2yMAxmgrBNWnEuGRfVQn5-Rd6HbcQGkpY4PkzNBUKnK_TLDKD95AL2apeU-rySOOuaU4nU5g0KVw84RbTJeYy_EHxdBTaGlCI4PUc_mrjTjOrFTY1uatrilSL86bnQbTdC_x_9Zx8CcgWWn-NoHkIcep3NbgjRoTXWJ83fSPwEHI2tkg
CitedBy_id crossref_primary_10_1016_j_jprot_2010_06_002
crossref_primary_10_1002_pmic_201300151
crossref_primary_10_1021_jasms_3c00111
crossref_primary_10_1074_mcp_M111_016568
crossref_primary_10_4155_bfs_11_7
crossref_primary_10_1177_0269881111430744
crossref_primary_10_1038_nprot_2013_083
crossref_primary_10_1002_pmic_201100353
crossref_primary_10_1007_s00216_012_5946_2
crossref_primary_10_1091_mbc_e13_10_0602
crossref_primary_10_1002_bip_22254
crossref_primary_10_1016_j_tibs_2012_07_001
crossref_primary_10_1021_pr4005579
crossref_primary_10_3390_molecules26072027
crossref_primary_10_1186_1471_2164_11_685
crossref_primary_10_1186_1471_2105_14_S14_S14
crossref_primary_10_1016_j_copbio_2010_09_005
crossref_primary_10_1042_BST20191219
crossref_primary_10_1002_pmic_202000034
crossref_primary_10_1021_cr300073p
crossref_primary_10_1098_rsta_2015_0364
crossref_primary_10_1186_1756_8935_4_19
crossref_primary_10_1016_j_aca_2011_07_012
crossref_primary_10_1021_pr400127j
crossref_primary_10_1016_j_bbrc_2010_11_133
crossref_primary_10_1146_annurev_anchem_061516_045237
crossref_primary_10_1155_2013_391984
crossref_primary_10_1002_pmic_201100520
crossref_primary_10_1021_ja106764y
crossref_primary_10_1016_j_jmb_2019_01_044
crossref_primary_10_1016_j_molcel_2015_06_022
crossref_primary_10_1002_pmic_201100386
crossref_primary_10_1038_s43586_021_00048_9
crossref_primary_10_1016_j_bbagrm_2014_03_002
crossref_primary_10_1021_acs_analchem_5b03679
crossref_primary_10_4155_fmc_10_246
crossref_primary_10_1002_pmic_201400084
crossref_primary_10_1021_pr4003883
crossref_primary_10_1074_mcp_M113_031633
crossref_primary_10_1021_pr300200x
crossref_primary_10_1002_0471140864_ps2307s77
crossref_primary_10_1002_pmic_201000786
crossref_primary_10_1021_pr100497a
crossref_primary_10_1021_pr401019d
Cites_doi 10.1021/ja973478k
10.1074/mcp.M700070-MCP200
10.1016/S0021-9258(18)82216-5
10.1093/emboj/cdg127
10.1074/jbc.M704194200
10.1101/gad.12.18.2831
10.1074/jbc.275.15.11514
10.1021/bi00107a022
10.1073/pnas.0402700101
10.1074/mcp.T500029-MCP200
10.1074/jbc.M513462200
10.1074/jbc.C200538200
10.1016/0003-2697(86)90195-8
10.1021/ac011083k
10.1126/science.1140321
10.1038/nature02017
10.1016/j.cell.2006.10.043
10.1038/ncb1717
10.1016/j.cell.2008.03.025
10.1073/pnas.0610993104
10.1242/jcs.01160
10.1128/MCB.21.8.2743-2754.2001
10.1016/S0014-5793(99)01647-6
10.1074/mcp.M600255-MCP200
10.1074/jbc.M709796200
10.1128/MCB.00460-07
10.1038/nrm1260
10.1586/14789450.5.1.105
10.1016/j.bbapap.2008.04.028
10.1083/jcb.200512059
10.1038/nature01116
10.1016/j.dnarep.2009.01.010
10.1186/1471-2121-2-12
10.1073/pnas.0502413102
10.1016/0968-0004(90)90236-5
10.1038/sj.onc.1204060
10.1002/prot.22104
10.1074/jbc.C200578200
10.1016/S0021-9258(19)36903-0
10.1038/sj.emboj.7601838
10.1074/mcp.M800487-MCP200
10.1016/0021-9673(94)85172-7
10.1016/0014-4827(89)90352-2
10.1074/jbc.M509266200
10.1016/j.molcel.2006.11.026
10.1038/3882
10.1091/mbc.4.6.615
10.1038/nature03114
10.1091/mbc.01-05-0224
10.1016/0014-5793(85)81085-1
10.1074/mcp.T500042-MCP200
10.1093/emboj/20.7.1630
10.1002/pmic.200800069
10.1074/jbc.M408324200
10.1016/0014-5793(77)80968-X
10.1101/gad.1055503
10.1126/science.7992051
10.1038/nature06092
10.1074/mcp.M400041-MCP200
10.1038/542
10.1021/bi00432a050
10.1083/jcb.200512058
10.1074/jbc.M806020200
10.1016/j.tcb.2005.08.002
10.1074/mcp.M800025-MCP200
10.4161/cc.5.5.2514
10.1093/emboj/16.19.6008
10.1016/j.cub.2006.09.014
10.1021/ac7025173
10.1074/jbc.M212574200
10.1038/ncb1470
10.1091/mbc.E04-08-0689
10.4161/cc.6.17.4633
10.1016/j.molcel.2006.11.021
10.1128/MCB.20.22.8458-8467.2000
10.1038/sj.emboj.7601839
10.1128/MCB.19.5.3466
10.1016/S0021-9258(19)42896-2
10.1016/j.molcel.2007.04.012
10.1083/jcb.100.3.764
10.1038/376771a0
10.1002/1096-9888(200012)35:12<1399::AID-JMS86>3.0.CO;2-R
10.1016/j.molcel.2009.04.016
10.4161/cc.3.4.769
10.1016/S0898-6568(97)00119-8
10.1093/emboj/18.22.6462
10.1074/jbc.M805658200
10.1016/j.molcel.2007.09.006
10.1021/bi000378+
10.1242/jcs.107.6.1529
10.1038/nature04254
10.1021/bi00323a034
10.1038/nmeth1052
10.1021/pr050268v
10.1016/S0021-9258(19)42895-0
10.1038/ncb714
10.1021/bi050906n
10.1074/jbc.M609001200
10.1083/jcb.120.3.725
10.1073/pnas.0710515105
10.1126/science.1967194
10.1038/ncb1716
10.1038/sj.onc.1203709
10.1016/j.cell.2004.06.016
10.1073/pnas.96.24.13777
10.1021/pr050269n
10.1074/mcp.M900238-MCP200
10.1016/j.ijms.2004.02.023
10.1016/j.molcel.2007.07.012
10.1002/elps.200800094
10.1038/47412
10.1038/sj.onc.1208173
10.1016/S0021-9258(18)54874-2
10.1073/pnas.0606775103
10.1091/mbc.8.4.637
10.1074/jbc.M706025200
10.1021/bi049833i
10.1016/j.cell.2006.09.031
10.1126/science.1113010
10.1091/mbc.8.4.621
10.1038/nature04219
10.1016/j.molcel.2006.12.010
10.1016/S0092-8674(00)80521-8
10.1038/nature03117
10.1021/bi952424p
10.1016/0168-9525(94)90232-1
10.1016/j.cell.2007.02.005
10.1038/nmeth1097
10.1016/j.cbpa.2006.11.022
10.1128/MCB.20.13.4666-4679.2000
10.1038/nature01120
10.1128/MCB.25.13.5380-5388.2005
10.1006/bbrc.2001.5043
10.1021/pr050266a
10.1038/nature05287
10.1016/j.ceb.2007.11.010
10.1016/j.jasms.2008.03.007
10.1016/j.tcb.2009.02.003
10.1006/bbrc.1998.8471
ContentType Journal Article
Copyright Expert Reviews Ltd 2010
COPYRIGHT 2010 Expert Reviews Ltd.
2010 Expert Reviews Ltd
Copyright_xml – notice: Expert Reviews Ltd 2010
– notice: COPYRIGHT 2010 Expert Reviews Ltd.
– notice: 2010 Expert Reviews Ltd
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7X7
7XB
88E
8AO
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M7P
PQEST
PQQKQ
PQUKI
PRINS
7X8
DOI 10.1586/epr.09.100
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
AUTh Library subscriptions: ProQuest Central
ProQuest Natural Science Collection
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection (Proquest) (PQ_SDU_P3)
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Biological Science Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
ProQuest Central Student
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central China
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic

MEDLINE
ProQuest Central Student
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: AUTh Library subscriptions: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
EISSN 1744-8387
EndPage 92
ExternalDocumentID 2065316661
A251006305
10_1586_epr_09_100
20121478
11217171
Genre Review
Research Support, U.S. Gov't, Non-P.H.S
Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations United States
GeographicLocations_xml – name: United States
GroupedDBID ---
0BK
0R~
0VX
29G
3V.
4.4
53G
5GY
7X7
88E
8AO
8CJ
8FE
8FH
8FI
8FJ
AAGSP
AAOUU
ABEIZ
ABJXJ
ABLKL
ABUWG
ACGFS
ACPRK
ADBBV
AECIN
AENEX
AEOZL
AFKRA
AGDLA
AGMLL
AHMBA
AIJEM
AIYSM
AKBVH
ALMA_UNASSIGNED_HOLDINGS
ALQZU
BBNVY
BENPR
BHPHI
BLEHA
BPHCQ
BVXVI
CCCUG
CS3
D1J
DU5
EBS
EJD
F5P
FYUFA
H13
HCIFZ
HZ~
IAO
IEA
IGS
IHR
ITC
KYCEM
LK8
M1P
M4Z
M7P
MV1
O9-
OVD
P2P
PQEST
PQQKQ
PQUKI
PROAC
PSQYO
RFE
RNANH
TCNNB
TEORI
TFL
TFW
UKHRP
AAHJP
AANCX
ABJNI
ABKMU
ABXYU
ACFRI
ACNPW
AESAV
ALIPV
CBZEQ
CCPQU
CGR
CUY
CVF
DDEWX
DGYZD
ECM
EIF
HMCUK
LJTGL
NPM
TBQAZ
TDBHL
TUROJ
AAYXX
CITATION
7XB
8FK
AZQEC
DWQXO
GNUQQ
K9.
PRINS
7X8
ID FETCH-LOGICAL-c471t-518c3317687a1059bf50942ebe6c57cc4b7d4f552201816840c7475387754ee23
IEDL.DBID 7X7
ISSN 1478-9450
IngestDate Fri Oct 25 02:51:20 EDT 2024
Thu Oct 10 16:44:13 EDT 2024
Thu Feb 22 23:34:45 EST 2024
Sat Dec 16 00:29:47 EST 2023
Fri Aug 23 05:03:44 EDT 2024
Tue Oct 15 23:38:57 EDT 2024
Tue Jun 13 19:29:17 EDT 2023
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c471t-518c3317687a1059bf50942ebe6c57cc4b7d4f552201816840c7475387754ee23
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
PMID 20121478
PQID 517484034
PQPubID 54583
PageCount 14
ParticipantIDs proquest_miscellaneous_733513422
informaworld_taylorfrancis_310_1586_epr_09_100
gale_infotracmisc_A251006305
proquest_journals_517484034
gale_infotracacademiconefile_A251006305
crossref_primary_10_1586_epr_09_100
pubmed_primary_20121478
PublicationCentury 2000
PublicationDate 2/1/2010
2010-Feb
2010-02-00
20100201
PublicationDateYYYYMMDD 2010-02-01
PublicationDate_xml – month: 02
  year: 2010
  text: 2/1/2010
  day: 01
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Expert review of proteomics
PublicationTitleAlternate Expert Rev Proteomics
PublicationYear 2010
Publisher Taylor & Francis
Expert Reviews Ltd
Informa Healthcare
Publisher_xml – name: Taylor & Francis
– name: Expert Reviews Ltd
– name: Informa Healthcare
References CIT0072
CIT0071
CIT0074
CIT0073
Garcia (CIT0022) 2007; 11
Jiang (CIT0137) 2007; 282
CIT0070
Redeker (CIT0085) 1994; 266
Siuti (CIT0139) 2006; 5
Price (CIT0052) 1995; 11
CIT0113
CIT0079
CIT0112
Reeves (CIT0110) 1996; 35
CIT0116
Youmell (CIT0062) 1998; 245
CIT0118
Yeh (CIT0041) 2001; 284
CIT0084
CIT0001
CIT0122
Chiappetta (CIT0105) 1995; 10
CIT0121
Ersfeld (CIT0086) 1993; 120
Chiappetta (CIT0108) 1996; 13
Dumaz (CIT0030) 1999; 463
Eipper (CIT0093) 1974; 249
CIT0003
Edberg (CIT0120) 2004; 43
CIT0124
CIT0002
CIT0123
CIT0005
Lund (CIT0115) 1985; 180
Banks (CIT0119) 2000; 39
Wisniewski (CIT0145) 2008; 73
CIT0006
Elton (CIT0114) 1986; 157
CIT0127
CIT0009
van Dijk (CIT0083) 2007; 26
CIT0010
CIT0098
CIT0131
CIT0097
CIT0012
Soufi (CIT0144) 2008; 8
CIT0011
CIT0099
CIT0132
CIT0091
Macek (CIT0126) 2006; 5
Hallak (CIT0087) 1977; 73
Ulrich (CIT0007) 2005; 15
Giancotti (CIT0106) 1985; 45
Berger (CIT0043) 2005; 25
CIT0014
CIT0135
CIT0013
CIT0016
CIT0015
CIT0136
CIT0018
CIT0017
Mayya (CIT0143) 2006; 5
CIT0021
Gard (CIT0094) 1985; 100
CIT0142
CIT0020
Audebert (CIT0082) 1993; 4
CIT0023
Garcia (CIT0004) 2005; 44
Medzihradszky (CIT0138) 2004; 3
Counterman (CIT0078) 2002; 74
CIT0025
CIT0024
CIT0027
Siuti (CIT0128) 2007; 4
CIT0026
CIT0029
Giancotti (CIT0107) 1989; 184
Stewart (CIT0067) 2001; 20
CIT0033
Xu (CIT0076) 2004; 3
Friebe (CIT0077) 1994; 661
Lindner (CIT0129) 2008; 29
Paturle (CIT0088) 1989; 28
Eipper (CIT0092) 1974; 249
CIT0036
CIT0035
Kelly (CIT0075) 1993; 268
Paturle-Lafanechere (CIT0090) 1991; 30
CIT0038
CIT0037
CIT0039
Wang (CIT0051) 2003; 278
Reeves (CIT0111) 1993; 268
CIT0040
Buschmann (CIT0042) 2001; 21
Edde (CIT0081) 1990; 247
Ou (CIT0056) 2005; 16
CIT0045
CIT0044
Nissen (CIT0117) 1991; 266
Garcia (CIT0133) 2007; 4
Bonenfant (CIT0130) 2006; 6
Thomas (CIT0141) 2006; 5
CIT0047
CIT0046
Phanstiel (CIT0134) 2008; 105
CIT0049
CIT0048
CIT0050
Redeker (CIT0100) 2005; 280
CIT0054
CIT0053
CIT0055
Caron (CIT0095) 1997; 8
Zubarev (CIT0125) 2008; 19
Ozols (CIT0096) 1997; 8
Boyne (CIT0140) 2006; 5
Okorokov (CIT0032) 1997; 16
Milne (CIT0028) 1992; 7
CIT0058
CIT0057
CIT0059
CIT0061
Bonisch (CIT0019) 2008; 5
CIT0060
CIT0063
Turenne (CIT0034) 2001; 2
CIT0065
CIT0064
Heideker (CIT0008) 2009; 8
CIT0066
Li (CIT0069) 2007; 28
Ewing (CIT0080) 2008; 80
Lopez-Borges (CIT0031) 2000; 19
Paturle-Lafanechere (CIT0089) 1994; 107
CIT0109
CIT0102
CIT0068
CIT0101
CIT0104
CIT0103
References_xml – ident: CIT0123
  doi: 10.1021/ja973478k
– volume: 6
  start-page: 1917
  year: 2006
  ident: CIT0130
  publication-title: Mol. Cell Proteomics
  doi: 10.1074/mcp.M700070-MCP200
  contributor:
    fullname: Bonenfant
– volume: 268
  start-page: 10416
  year: 1993
  ident: CIT0075
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)82216-5
  contributor:
    fullname: Kelly
– ident: CIT0048
  doi: 10.1093/emboj/cdg127
– volume: 282
  start-page: 27923
  year: 2007
  ident: CIT0137
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M704194200
  contributor:
    fullname: Jiang
– ident: CIT0037
  doi: 10.1101/gad.12.18.2831
– ident: CIT0121
  doi: 10.1074/jbc.275.15.11514
– volume: 30
  start-page: 10523
  year: 1991
  ident: CIT0090
  publication-title: Biochemistry
  doi: 10.1021/bi00107a022
  contributor:
    fullname: Paturle-Lafanechere
– ident: CIT0124
  doi: 10.1073/pnas.0402700101
– volume: 5
  start-page: 1146
  year: 2006
  ident: CIT0143
  publication-title: Mol. Cell. Proteomics
  doi: 10.1074/mcp.T500029-MCP200
  contributor:
    fullname: Mayya
– ident: CIT0015
  doi: 10.1074/jbc.M513462200
– ident: CIT0038
  doi: 10.1074/jbc.C200538200
– volume: 157
  start-page: 53
  year: 1986
  ident: CIT0114
  publication-title: Anal. Biochem.
  doi: 10.1016/0003-2697(86)90195-8
  contributor:
    fullname: Elton
– volume: 74
  start-page: 1946
  year: 2002
  ident: CIT0078
  publication-title: Anal. Chem.
  doi: 10.1021/ac011083k
  contributor:
    fullname: Counterman
– ident: CIT0044
  doi: 10.1126/science.1140321
– ident: CIT0003
  doi: 10.1038/nature02017
– ident: CIT0016
  doi: 10.1016/j.cell.2006.10.043
– ident: CIT0013
  doi: 10.1038/ncb1717
– ident: CIT0050
  doi: 10.1016/j.cell.2008.03.025
– ident: CIT0142
  doi: 10.1073/pnas.0610993104
– ident: CIT0118
  doi: 10.1242/jcs.01160
– volume: 21
  start-page: 2743
  year: 2001
  ident: CIT0042
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.21.8.2743-2754.2001
  contributor:
    fullname: Buschmann
– volume: 463
  start-page: 312
  year: 1999
  ident: CIT0030
  publication-title: FEBS Lett.
  doi: 10.1016/S0014-5793(99)01647-6
  contributor:
    fullname: Dumaz
– ident: CIT0006
  doi: 10.1074/mcp.M600255-MCP200
– ident: CIT0136
  doi: 10.1074/jbc.M709796200
– ident: CIT0070
  doi: 10.1128/MCB.00460-07
– ident: CIT0103
  doi: 10.1038/nrm1260
– volume: 5
  start-page: 105
  year: 2008
  ident: CIT0019
  publication-title: Exp. Rev. Proteomics
  doi: 10.1586/14789450.5.1.105
  contributor:
    fullname: Bonisch
– ident: CIT0113
  doi: 10.1016/j.bbapap.2008.04.028
– ident: CIT0068
  doi: 10.1083/jcb.200512059
– ident: CIT0036
  doi: 10.1038/nature01116
– volume: 8
  start-page: 517
  year: 2009
  ident: CIT0008
  publication-title: DNA Repair (Amst.)
  doi: 10.1016/j.dnarep.2009.01.010
  contributor:
    fullname: Heideker
– volume: 2
  start-page: 12
  year: 2001
  ident: CIT0034
  publication-title: BMC Cell. Biol.
  doi: 10.1186/1471-2121-2-12
  contributor:
    fullname: Turenne
– ident: CIT0132
  doi: 10.1073/pnas.0502413102
– ident: CIT0073
  doi: 10.1016/0968-0004(90)90236-5
– volume: 20
  start-page: 113
  year: 2001
  ident: CIT0067
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1204060
  contributor:
    fullname: Stewart
– volume: 73
  start-page: 710
  year: 2008
  ident: CIT0145
  publication-title: Proteins
  doi: 10.1002/prot.22104
  contributor:
    fullname: Wisniewski
– ident: CIT0027
  doi: 10.1074/jbc.C200578200
– volume: 268
  start-page: 21137
  year: 1993
  ident: CIT0111
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)36903-0
  contributor:
    fullname: Reeves
– ident: CIT0009
  doi: 10.1038/sj.emboj.7601838
– ident: CIT0025
  doi: 10.1074/mcp.M800487-MCP200
– volume: 661
  start-page: 7
  year: 1994
  ident: CIT0077
  publication-title: J. Chromatogr. A
  doi: 10.1016/0021-9673(94)85172-7
  contributor:
    fullname: Friebe
– volume: 184
  start-page: 538
  year: 1989
  ident: CIT0107
  publication-title: Exp. Cell Res.
  doi: 10.1016/0014-4827(89)90352-2
  contributor:
    fullname: Giancotti
– volume: 11
  start-page: 73
  year: 1995
  ident: CIT0052
  publication-title: Oncogene
  contributor:
    fullname: Price
– ident: CIT0131
  doi: 10.1074/jbc.M509266200
– ident: CIT0046
  doi: 10.1016/j.molcel.2006.11.026
– ident: CIT0029
  doi: 10.1038/3882
– volume: 4
  start-page: 615
  year: 1993
  ident: CIT0082
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.4.6.615
  contributor:
    fullname: Audebert
– ident: CIT0017
  doi: 10.1038/nature03114
– ident: CIT0098
  doi: 10.1091/mbc.01-05-0224
– volume: 180
  start-page: 275
  year: 1985
  ident: CIT0115
  publication-title: FEBS Lett.
  doi: 10.1016/0014-5793(85)81085-1
  contributor:
    fullname: Lund
– volume: 5
  start-page: 949
  year: 2006
  ident: CIT0126
  publication-title: Mol. Cell. Proteomics
  doi: 10.1074/mcp.T500042-MCP200
  contributor:
    fullname: Macek
– ident: CIT0049
  doi: 10.1093/emboj/20.7.1630
– volume: 8
  start-page: 3486
  year: 2008
  ident: CIT0144
  publication-title: Proteomics
  doi: 10.1002/pmic.200800069
  contributor:
    fullname: Soufi
– volume: 280
  start-page: 596
  year: 2005
  ident: CIT0100
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M408324200
  contributor:
    fullname: Redeker
– volume: 73
  start-page: 147
  year: 1977
  ident: CIT0087
  publication-title: FEBS Lett.
  doi: 10.1016/0014-5793(77)80968-X
  contributor:
    fullname: Hallak
– ident: CIT0072
  doi: 10.1101/gad.1055503
– volume: 266
  start-page: 1688
  year: 1994
  ident: CIT0085
  publication-title: Science
  doi: 10.1126/science.7992051
  contributor:
    fullname: Redeker
– ident: CIT0059
  doi: 10.1038/nature06092
– volume: 3
  start-page: 872
  year: 2004
  ident: CIT0138
  publication-title: Mol. Cell Proteomics
  doi: 10.1074/mcp.M400041-MCP200
  contributor:
    fullname: Medzihradszky
– ident: CIT0064
  doi: 10.1038/542
– volume: 28
  start-page: 2698
  year: 1989
  ident: CIT0088
  publication-title: Biochemistry
  doi: 10.1021/bi00432a050
  contributor:
    fullname: Paturle
– ident: CIT0116
  doi: 10.1016/j.bbapap.2008.04.028
– ident: CIT0099
  doi: 10.1083/jcb.200512058
– ident: CIT0026
  doi: 10.1074/jbc.M806020200
– volume: 15
  start-page: 525
  year: 2005
  ident: CIT0007
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2005.08.002
  contributor:
    fullname: Ulrich
– ident: CIT0014
  doi: 10.1074/mcp.M800025-MCP200
– ident: CIT0035
  doi: 10.4161/cc.5.5.2514
– volume: 16
  start-page: 6008
  year: 1997
  ident: CIT0032
  publication-title: EMBO J.
  doi: 10.1093/emboj/16.19.6008
  contributor:
    fullname: Okorokov
– ident: CIT0097
  doi: 10.1016/j.cub.2006.09.014
– volume: 80
  start-page: 2874
  year: 2008
  ident: CIT0080
  publication-title: Anal. Chem.
  doi: 10.1021/ac7025173
  contributor:
    fullname: Ewing
– volume: 278
  start-page: 25568
  year: 2003
  ident: CIT0051
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M212574200
  contributor:
    fullname: Wang
– ident: CIT0047
  doi: 10.1038/ncb1470
– volume: 16
  start-page: 1684
  year: 2005
  ident: CIT0056
  publication-title: Mol. Biol. Cell.
  doi: 10.1091/mbc.E04-08-0689
  contributor:
    fullname: Ou
– ident: CIT0102
  doi: 10.4161/cc.6.17.4633
– ident: CIT0045
  doi: 10.1016/j.molcel.2006.11.021
– ident: CIT0060
  doi: 10.1128/MCB.20.22.8458-8467.2000
– ident: CIT0011
  doi: 10.1038/sj.emboj.7601839
– ident: CIT0122
  doi: 10.1128/MCB.19.5.3466
– volume: 249
  start-page: 1407
  year: 1974
  ident: CIT0092
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)42896-2
  contributor:
    fullname: Eipper
– volume: 26
  start-page: 437
  year: 2007
  ident: CIT0083
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2007.04.012
  contributor:
    fullname: van Dijk
– volume: 100
  start-page: 764
  year: 1985
  ident: CIT0094
  publication-title: J. Cell. Biol.
  doi: 10.1083/jcb.100.3.764
  contributor:
    fullname: Gard
– volume: 13
  start-page: 2439
  year: 1996
  ident: CIT0108
  publication-title: Oncogene
  contributor:
    fullname: Chiappetta
– ident: CIT0109
  doi: 10.1038/376771a0
– ident: CIT0127
  doi: 10.1002/1096-9888(200012)35:12<1399::AID-JMS86>3.0.CO;2-R
– ident: CIT0074
  doi: 10.1016/j.molcel.2009.04.016
– volume: 3
  start-page: 432
  year: 2004
  ident: CIT0076
  publication-title: Cell Cycle
  doi: 10.4161/cc.3.4.769
  contributor:
    fullname: Xu
– ident: CIT0071
  doi: 10.1016/S0898-6568(97)00119-8
– ident: CIT0066
  doi: 10.1093/emboj/18.22.6462
– ident: CIT0055
  doi: 10.1074/jbc.M805658200
– volume: 28
  start-page: 408
  year: 2007
  ident: CIT0069
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2007.09.006
  contributor:
    fullname: Li
– volume: 39
  start-page: 8333
  year: 2000
  ident: CIT0119
  publication-title: Biochemistry
  doi: 10.1021/bi000378+
  contributor:
    fullname: Banks
– volume: 107
  start-page: 1529
  year: 1994
  ident: CIT0089
  publication-title: J. Cell. Sci.
  doi: 10.1242/jcs.107.6.1529
  contributor:
    fullname: Paturle-Lafanechere
– ident: CIT0001
  doi: 10.1038/nature04254
– ident: CIT0091
  doi: 10.1021/bi00323a034
– volume: 4
  start-page: 487
  year: 2007
  ident: CIT0133
  publication-title: Nat. Methods
  doi: 10.1038/nmeth1052
  contributor:
    fullname: Garcia
– volume: 5
  start-page: 233
  year: 2006
  ident: CIT0139
  publication-title: J. Proteome Res.
  doi: 10.1021/pr050268v
  contributor:
    fullname: Siuti
– volume: 249
  start-page: 1398
  year: 1974
  ident: CIT0093
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)42895-0
  contributor:
    fullname: Eipper
– ident: CIT0040
  doi: 10.1038/ncb714
– volume: 44
  start-page: 13202
  year: 2005
  ident: CIT0004
  publication-title: Biochemistry
  doi: 10.1021/bi050906n
  contributor:
    fullname: Garcia
– ident: CIT0054
  doi: 10.1074/jbc.M609001200
– volume: 120
  start-page: 725
  year: 1993
  ident: CIT0086
  publication-title: J. Cell. Biol.
  doi: 10.1083/jcb.120.3.725
  contributor:
    fullname: Ersfeld
– volume: 105
  start-page: 4093
  year: 2008
  ident: CIT0134
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0710515105
  contributor:
    fullname: Phanstiel
– volume: 247
  start-page: 83
  year: 1990
  ident: CIT0081
  publication-title: Science
  doi: 10.1126/science.1967194
  contributor:
    fullname: Edde
– ident: CIT0012
  doi: 10.1038/ncb1716
– volume: 19
  start-page: 3656
  year: 2000
  ident: CIT0031
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1203709
  contributor:
    fullname: Lopez-Borges
– ident: CIT0061
  doi: 10.1016/j.cell.2004.06.016
– ident: CIT0033
  doi: 10.1073/pnas.96.24.13777
– volume: 5
  start-page: 248
  year: 2006
  ident: CIT0140
  publication-title: J. Proteome Res.
  doi: 10.1021/pr050269n
  contributor:
    fullname: Boyne
– ident: CIT0135
  doi: 10.1074/mcp.M900238-MCP200
– ident: CIT0079
  doi: 10.1016/j.ijms.2004.02.023
– ident: CIT0065
  doi: 10.1016/j.molcel.2007.07.012
– volume: 29
  start-page: 2516
  year: 2008
  ident: CIT0129
  publication-title: Electrophoresis
  doi: 10.1002/elps.200800094
  contributor:
    fullname: Lindner
– ident: CIT0018
  doi: 10.1038/47412
– ident: CIT0023
  doi: 10.1038/sj.onc.1208173
– volume: 10
  start-page: 1307
  year: 1995
  ident: CIT0105
  publication-title: Oncogene
  contributor:
    fullname: Chiappetta
– volume: 266
  start-page: 19945
  year: 1991
  ident: CIT0117
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)54874-2
  contributor:
    fullname: Nissen
– ident: CIT0005
  doi: 10.1073/pnas.0606775103
– volume: 8
  start-page: 637
  year: 1997
  ident: CIT0096
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.8.4.637
  contributor:
    fullname: Ozols
– ident: CIT0010
  doi: 10.1074/jbc.M706025200
– volume: 7
  start-page: 1361
  year: 1992
  ident: CIT0028
  publication-title: Oncogene
  contributor:
    fullname: Milne
– volume: 43
  start-page: 11500
  year: 2004
  ident: CIT0120
  publication-title: Biochemistry
  doi: 10.1021/bi049833i
  contributor:
    fullname: Edberg
– ident: CIT0053
  doi: 10.1016/j.cell.2006.09.031
– ident: CIT0084
  doi: 10.1126/science.1113010
– volume: 8
  start-page: 621
  year: 1997
  ident: CIT0095
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.8.4.621
  contributor:
    fullname: Caron
– ident: CIT0002
  doi: 10.1038/nature04219
– ident: CIT0020
  doi: 10.1016/j.molcel.2006.12.010
– ident: CIT0057
  doi: 10.1016/S0092-8674(00)80521-8
– ident: CIT0063
  doi: 10.1038/nature03117
– volume: 35
  start-page: 5063
  year: 1996
  ident: CIT0110
  publication-title: Biochemistry
  doi: 10.1021/bi952424p
  contributor:
    fullname: Reeves
– ident: CIT0104
  doi: 10.1016/0168-9525(94)90232-1
– ident: CIT0021
  doi: 10.1016/j.cell.2007.02.005
– volume: 4
  start-page: 817
  year: 2007
  ident: CIT0128
  publication-title: Nat. Methods
  doi: 10.1038/nmeth1097
  contributor:
    fullname: Siuti
– volume: 11
  start-page: 66
  year: 2007
  ident: CIT0022
  publication-title: Curr. Opin. Chem. Biol.
  doi: 10.1016/j.cbpa.2006.11.022
  contributor:
    fullname: Garcia
– ident: CIT0112
  doi: 10.1128/MCB.20.13.4666-4679.2000
– ident: CIT0039
  doi: 10.1038/nature01120
– volume: 25
  start-page: 5380
  year: 2005
  ident: CIT0043
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.25.13.5380-5388.2005
  contributor:
    fullname: Berger
– volume: 284
  start-page: 880
  year: 2001
  ident: CIT0041
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1006/bbrc.2001.5043
  contributor:
    fullname: Yeh
– volume: 5
  start-page: 240
  year: 2006
  ident: CIT0141
  publication-title: J. Proteome Res.
  doi: 10.1021/pr050266a
  contributor:
    fullname: Thomas
– ident: CIT0058
  doi: 10.1038/nature05287
– ident: CIT0101
  doi: 10.1016/j.ceb.2007.11.010
– volume: 19
  start-page: 753
  year: 2008
  ident: CIT0125
  publication-title: J. Am. Soc. Mass Spectrom.
  doi: 10.1016/j.jasms.2008.03.007
  contributor:
    fullname: Zubarev
– ident: CIT0024
  doi: 10.1016/j.tcb.2009.02.003
– volume: 45
  start-page: 6051
  year: 1985
  ident: CIT0106
  publication-title: Cancer Res.
  contributor:
    fullname: Giancotti
– volume: 245
  start-page: 514
  year: 1998
  ident: CIT0062
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1006/bbrc.1998.8471
  contributor:
    fullname: Youmell
SSID ssj0034956
Score 2.1360962
SecondaryResourceType review_article
Snippet Protein post-translational modifications (PTMs) have been widely shown to influence protein-protein interactions, direct subcellular location and transduce a...
Protein post-translational modifications (PTMs) have been widely shown to influence protein-âprotein interactions, direct subcellular location and transduce a...
SourceID proquest
gale
crossref
pubmed
informaworld
SourceType Aggregation Database
Index Database
Publisher
StartPage 79
SubjectTerms electron-capture dissociation
electron-transfer dissociation
histone code
Mass spectrometry
Mass Spectrometry - methods
Methods
middle-down approach
Observations
Post-translational modification
Properties
Protein Processing, Post-Translational
Proteins - analysis
Proteomics
Proteomics - methods
top-down approach
Title Systems-wide proteomic characterization of combinatorial post-translational modification patterns
URI https://www.tandfonline.com/doi/abs/10.1586/epr.09.100
https://www.ncbi.nlm.nih.gov/pubmed/20121478
https://www.proquest.com/docview/517484034
https://search.proquest.com/docview/733513422
Volume 7
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3PS-UwEB529eIexF1_VV0JKHiqviZN2ndaVBTZgyyi8G6hSVMQtK2vFf99Z9K88h7s7jltQyaTyfelM18ATpXKkgLpTuwQ3CNBMZPYKKpYnnKXmdxhQPRZvvfq7in9PZOzkJvThbTKRUz0gbpsLJ2RX5CiMpIRkf5q32K6NIp-roYbNL7CesInipw6m418SxD298VFSJSmqZwEdVKZqwvXzkneNKHCtqX9KETlFdHSf0NPvwXdbsFmwI7scpjs7_DF1T_g25Ki4DYUQYE8_nguHfMiDFR2zOyoyzyUXbKmYjhupMVEutEHWdt0fdzTzvUSzgfZa1NSItHwQuuFOOtuB55ubx6v7-Jwi0JscePpY5nkViBKUHlWEJgyFWnmcZw8ZWVmbWqyMq0k4jDS7iLtF4sUA-MgaeM5x8UurNVN7faBJSUyNslVxgtc-87klTROIiAzRSKUMxGcLGyp20EsQxPJQItrtLieTEkiOYIzMrMmI-OwbBEKAbAP0qLSlwi5vBSYjOBo5Un0fLvSfL48Ubr3ZxzVcCGJFn_r-XAxlTos1U6PjhUBG1upJ8o-q13z3ulMCJmIlPMI9gYHGIfHSRMPHezgv58-hI0h64DSYI5grZ-_u58IZnpz7F32GNavbu7_PHwCmnz0Gg
link.rule.ids 315,783,787,12069,21401,27937,27938,31732,31733,33757,33758,43323,43818,74080,74637
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfZ1NT-MwEIZHfBxgDwh2gQ1fa4mVOAWaOHbSE0IIVHaBE0i9WbHjSEiQBBK0f39nHDdqJeCctpbHk_G87sxjgN9SplGOcie0mNyjQNGjUEvqWB7HNtWZxYDoqnzv5eQx-TMVU1-b0_qyyllMdIG6qA2dkZ8RURnFCE_Om9eQLo2iP1f9DRrLsEoYLnLzdDroLU65v2suQqE0TsTI00lFJs9s80Z404ga2-b2Ix-VF6Cln6eebgu63oQNnzuyi36xt2DJVt_h2xxR8AfknkAe_nsqLHMQBmo7ZmbgMvdtl6wuGc4bZTGJbvRB1tRtF3a0cz3780H2UhdUSNR_oXEgzqrdhsfrq4fLSehvUQgNbjxdKKLMcMwSZJbmlEzpkph5MS6eNCI1JtFpkZQC8zBidxH7xaDEwDhIbDxrY74DK1Vd2Z_AogIVm4hlGuf47ludlUJbgQmZziMurQ7geGZL1fSwDEUiAy2u0OJqNCZEcgAnZGZFRsZpmdw3AuAYxKJSF5hyORSYCOBg4ZPo-Wbh8en8QqnOnXGU_YUkin808v5sKZV_VVs1OFYAbHhKI1H1WWXr91alnIuIJ3EcwG7vAMP0YmLioYPtffnTv2Bt8nB3q25v7v_uw3pfgUAlMQew0r2920NMbDp95Nz3P3mB9Wc
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfZ1Ra9swEMePrYXRPoytXVuv2SZYoU9eYsuSnaeRbQnZOkIYDfRNWLIMhdZ2a5d-_d7Zckig3bPtCJ_Op_srdz8BnEkZBynKHd9ico8CRY98LaljeRzaWCcWA2Jb5buQ81X050pcOaRQ7coq-5jYBuqsNLRHPiSiMooRHg1zVxWx_DX7Xt35dIAU_dHqTtN4DbtxJDnqsN0f08XyXx-WOSmBttUIZdM4EiPHKhWJHNrqnmCnAbW5baxOLkZvIUxfTkTbBWn2Dt66TJJNuql_D69scQD7G3zBQ0gdj9x_vM4sa5EM1ITMzJrS3DVhsjJnaAUUySTB0SNZVdaN39A6duN2C9ltmVFZUfdA1WI5i_oDrGbTy59z352p4BtchhpfBInhmDPIJE4ptdI5EfRCnEppRGxMpOMsygVmZUTyIhKMQcGBUZFIedaG_Ah2irKwJ8CCDPWbCGUcphgJrE5yoa3A9EynAZdWe_C1t6WqOnSGIsmBFldocTUaEzDZg3MysyIj42uZ1LUF4BhEplITTMBaMJjwYLB1J34HZuvyt82JUk2745F3x5Mo_tzIp_1UKvfh1mrtZh6w9VUaiWrRCls-1CrmXAQ8CkMPjjsHWL9eSIQ8dLCP__3pL_AGfVf9_b24OIW9rhyB6mMGsNPcP9hPmOU0-rPz3yc_nvsK
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Systems-wide+proteomic+characterization+of+combinatorial+post-translational+modification+patterns&rft.jtitle=Expert+review+of+proteomics&rft.au=Young%2C+Nicolas+L&rft.au=Plazas-Mayorca%2C+Mariana+D&rft.au=Garcia%2C+Benjamin+A&rft.date=2010-02-01&rft.pub=Informa+Healthcare&rft.issn=1478-9450&rft.eissn=1744-8387&rft.volume=7&rft.issue=1&rft.spage=79&rft_id=info:doi/10.1586%2Fepr.09.100&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=2065316661
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1478-9450&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1478-9450&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1478-9450&client=summon