Recent Advancement in Fluorescent Probes for Peroxynitrite (ONOO−)

Peroxynitrite (ONOO−) is a reactive nitrogen species (RNS) that plays pivotal roles in various physiological and pathological processes. The recent literature has seen significant progress in the development of highly sensitive and selective fluorescent probes applicable for monitoring ONOO− dynamic...

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Published inSensors (Basel, Switzerland) Vol. 25; no. 10; p. 3018
Main Authors Han, Hai-Hao, Ge, Pan-Xin, Li, Wen-Jia, Hu, Xi-Le, He, Xiao-Peng
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 10.05.2025
MDPI
Subjects
Acids
Animals
Apoptosis
bioimaging
Biosensing Techniques - methods
Boron
Chromatography
Disease
disease diagnosis and treatment
Ferroptosis
Fluorescent Dyes - chemistry
fluorescent probes
Humans
in vivo
Medical diagnosis
Medical research
Nitric oxide
Oxidation
Oxidative stress
peroxynitrite (ONOO−)
Peroxynitrous Acid - analysis
Peroxynitrous Acid - chemistry
Physiology
Reactive Nitrogen Species - chemistry
Reactive oxygen species
Review
Scientific imaging
Sedgwick, A.C
China
Timor-Leste
Israel
in vivo
peroxynitrite (ONOO−)
fluorescent probes
bioimaging
disease diagnosis and treatment
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Abstract Peroxynitrite (ONOO−) is a reactive nitrogen species (RNS) that plays pivotal roles in various physiological and pathological processes. The recent literature has seen significant progress in the development of highly sensitive and selective fluorescent probes applicable for monitoring ONOO− dynamics in live cells and a variety of animal models of human diseases. However, the clinical applications of those probes remain much less explored. This review delves into the biological roles of ONOO− and summarizes the design strategies, sensing mechanisms, and bioimaging applications of near-infrared (NIR), long-wavelength, two-photon, and ratiometric fluorescent probes modified with a diverse range of functional groups responsive to ONOO−. Furthermore, we will discuss the remaining problems that prevent the currently developed ONOO− probes from translating into clinical practice.
AbstractList Peroxynitrite (ONOO−) is a reactive nitrogen species (RNS) that plays pivotal roles in various physiological and pathological processes. The recent literature has seen significant progress in the development of highly sensitive and selective fluorescent probes applicable for monitoring ONOO− dynamics in live cells and a variety of animal models of human diseases. However, the clinical applications of those probes remain much less explored. This review delves into the biological roles of ONOO− and summarizes the design strategies, sensing mechanisms, and bioimaging applications of near-infrared (NIR), long-wavelength, two-photon, and ratiometric fluorescent probes modified with a diverse range of functional groups responsive to ONOO−. Furthermore, we will discuss the remaining problems that prevent the currently developed ONOO− probes from translating into clinical practice.
Peroxynitrite (ONOO ) is a reactive nitrogen species (RNS) that plays pivotal roles in various physiological and pathological processes. The recent literature has seen significant progress in the development of highly sensitive and selective fluorescent probes applicable for monitoring ONOO dynamics in live cells and a variety of animal models of human diseases. However, the clinical applications of those probes remain much less explored. This review delves into the biological roles of ONOO and summarizes the design strategies, sensing mechanisms, and bioimaging applications of near-infrared (NIR), long-wavelength, two-photon, and ratiometric fluorescent probes modified with a diverse range of functional groups responsive to ONOO . Furthermore, we will discuss the remaining problems that prevent the currently developed ONOO probes from translating into clinical practice.
Peroxynitrite (ONOO-) is a reactive nitrogen species (RNS) that plays pivotal roles in various physiological and pathological processes. The recent literature has seen significant progress in the development of highly sensitive and selective fluorescent probes applicable for monitoring ONOO- dynamics in live cells and a variety of animal models of human diseases. However, the clinical applications of those probes remain much less explored. This review delves into the biological roles of ONOO- and summarizes the design strategies, sensing mechanisms, and bioimaging applications of near-infrared (NIR), long-wavelength, two-photon, and ratiometric fluorescent probes modified with a diverse range of functional groups responsive to ONOO-. Furthermore, we will discuss the remaining problems that prevent the currently developed ONOO- probes from translating into clinical practice.Peroxynitrite (ONOO-) is a reactive nitrogen species (RNS) that plays pivotal roles in various physiological and pathological processes. The recent literature has seen significant progress in the development of highly sensitive and selective fluorescent probes applicable for monitoring ONOO- dynamics in live cells and a variety of animal models of human diseases. However, the clinical applications of those probes remain much less explored. This review delves into the biological roles of ONOO- and summarizes the design strategies, sensing mechanisms, and bioimaging applications of near-infrared (NIR), long-wavelength, two-photon, and ratiometric fluorescent probes modified with a diverse range of functional groups responsive to ONOO-. Furthermore, we will discuss the remaining problems that prevent the currently developed ONOO- probes from translating into clinical practice.
Peroxynitrite (ONOO − ) is a reactive nitrogen species (RNS) that plays pivotal roles in various physiological and pathological processes. The recent literature has seen significant progress in the development of highly sensitive and selective fluorescent probes applicable for monitoring ONOO − dynamics in live cells and a variety of animal models of human diseases. However, the clinical applications of those probes remain much less explored. This review delves into the biological roles of ONOO − and summarizes the design strategies, sensing mechanisms, and bioimaging applications of near-infrared (NIR), long-wavelength, two-photon, and ratiometric fluorescent probes modified with a diverse range of functional groups responsive to ONOO − . Furthermore, we will discuss the remaining problems that prevent the currently developed ONOO − probes from translating into clinical practice.
Peroxynitrite (ONOO[sup.−]) is a reactive nitrogen species (RNS) that plays pivotal roles in various physiological and pathological processes. The recent literature has seen significant progress in the development of highly sensitive and selective fluorescent probes applicable for monitoring ONOO[sup.−] dynamics in live cells and a variety of animal models of human diseases. However, the clinical applications of those probes remain much less explored. This review delves into the biological roles of ONOO[sup.−] and summarizes the design strategies, sensing mechanisms, and bioimaging applications of near-infrared (NIR), long-wavelength, two-photon, and ratiometric fluorescent probes modified with a diverse range of functional groups responsive to ONOO[sup.−]. Furthermore, we will discuss the remaining problems that prevent the currently developed ONOO[sup.−] probes from translating into clinical practice.
Audience Academic
Author Han, Hai-Hao
Hu, Xi-Le
Li, Wen-Jia
Ge, Pan-Xin
He, Xiao-Peng
AuthorAffiliation 1 Key Laboratory for Advanced Materials and Joint International Research, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, China; hanhaihao@simm.ac.cn (H.-H.H.); xlhu@ecust.edu.cn (X.-L.H.)
7 University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China
9 The International Cooperation Laboratory on Signal Transduction, National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China
2 Laboratory of Precision Chemistry and Molecular Engineering, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, China
4 Frontiers Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, China
5 Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute
AuthorAffiliation_xml – name: 4 Frontiers Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, China
– name: 7 University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China
– name: 3 Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, China
– name: 1 Key Laboratory for Advanced Materials and Joint International Research, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, China; hanhaihao@simm.ac.cn (H.-H.H.); xlhu@ecust.edu.cn (X.-L.H.)
– name: 2 Laboratory of Precision Chemistry and Molecular Engineering, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, China
– name: 6 Molecular Imaging Center, National Center for Drug Screening, Stake Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
– name: 9 The International Cooperation Laboratory on Signal Transduction, National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China
– name: 5 Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China; 2023254227027@stu.ahtcm.edu.cn (P.-X.G.); liwenjia@simm.ac.cn (W.-J.L.)
– name: 8 School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China
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  orcidid: 0000-0001-5087-3828
  surname: Han
  fullname: Han, Hai-Hao
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  orcidid: 0009-0009-8107-387X
  surname: Ge
  fullname: Ge, Pan-Xin
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  surname: Li
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  orcidid: 0000-0002-8736-3511
  surname: He
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Keywords in vivo
peroxynitrite (ONOO−)
fluorescent probes
bioimaging
disease diagnosis and treatment
Language English
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RelatedPersons Sedgwick, A.C
RelatedPersons_xml – fullname: Sedgwick, A.C
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Snippet Peroxynitrite (ONOO−) is a reactive nitrogen species (RNS) that plays pivotal roles in various physiological and pathological processes. The recent literature...
Peroxynitrite (ONOO ) is a reactive nitrogen species (RNS) that plays pivotal roles in various physiological and pathological processes. The recent literature...
Peroxynitrite (ONOO[sup.−]) is a reactive nitrogen species (RNS) that plays pivotal roles in various physiological and pathological processes. The recent...
Peroxynitrite (ONOO-) is a reactive nitrogen species (RNS) that plays pivotal roles in various physiological and pathological processes. The recent literature...
Peroxynitrite (ONOO − ) is a reactive nitrogen species (RNS) that plays pivotal roles in various physiological and pathological processes. The recent...
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SubjectTerms Acids
Animals
Apoptosis
bioimaging
Biosensing Techniques - methods
Boron
Chromatography
Disease
disease diagnosis and treatment
Ferroptosis
Fluorescent Dyes - chemistry
fluorescent probes
Humans
in vivo
Medical diagnosis
Medical research
Nitric oxide
Oxidation
Oxidative stress
peroxynitrite (ONOO−)
Peroxynitrous Acid - analysis
Peroxynitrous Acid - chemistry
Physiology
Reactive Nitrogen Species - chemistry
Reactive oxygen species
Review
Scientific imaging
Sedgwick, A.C
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Title Recent Advancement in Fluorescent Probes for Peroxynitrite (ONOO−)
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Volume 25
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