Modulation of anterior cingulate cortex reward and penalty signalling in medication-naive young-adult subjects with depressive symptoms following acute dose lurasidone

• Published in: Psychological medicine Vol. 49; no. 8; pp. 1365 - 1377
• Main Authors: Wolke, Selina A., Mehta, Mitul A., O'Daly, Owen, Zelaya, Fernando, Zahreddine, Nada, Keren, Hanna, O'Callaghan, Georgia, Young, Allan H., Leibenluft, Ellen, Pine, Daniel S., Stringaris, Argyris
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.06.2019
• Subjects: Adolescent; Adult; Antidepressants; Biomedical research; Blood flow; Brain; Brain mapping; Brain research; Cerebral blood flow; Child & adolescent psychiatry; Cortex; Cortex (cingulate); Cross-Over Studies; Cues; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - physiopathology; Depressive personality disorders; Design; Dopamine; Dopamine D2 Receptor Antagonists - therapeutic use; Dopamine D2 receptors; Dopaminergic Neurons - drug effects; Dopaminergic Neurons - physiology; Double-Blind Method; Drug dosages; Expectations; Female; Fines & penalties; Functional magnetic resonance imaging; Funding; Gyrus Cinguli - drug effects; Gyrus Cinguli - physiopathology; Hostility; Humans; Information processing; Labelling; Lurasidone Hydrochloride - therapeutic use; Magnetic Resonance Imaging; Male; Medical research; Mental depression; Neostriatum; Neuroimaging; Neurosciences; Original; Original Articles; Pharmaceutical industry; Psychotropic drugs; Reinforcement; Research centers; Resting; Reward; Severity; Spin labeling; Volunteers; Young Adult; Young adults; United Kingdom > UK; United States > US; reward; lurasidone; fMRI; depression; Anterior cingulate cortex; penalty

Aberrations in reward and penalty processing are implicated in depression and putatively reflect altered dopamine signalling. This study exploits the advantages of a placebo-controlled design to examine how a novel D2 antagonist with adjunctive antidepressant properties modifies activity in the brai...