RANTES Potentiates Antigen-Specific Mucosal Immune Responses

• Published in: The Journal of immunology (1950) Vol. 166; no. 1; pp. 162 - 169
• Main Authors: Lillard, James W., Jr, Boyaka, Prosper N, Taub, Dennis D, McGhee, Jerry R
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 01.01.2001
• Subjects: Adjuvants, Immunologic - administration & dosage; Adjuvants, Immunologic - physiology; Administration, Intranasal; Animals; Antibody-Producing Cells - immunology; Antibody-Producing Cells - metabolism; B-Lymphocyte Subsets - immunology; B-Lymphocyte Subsets - metabolism; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; Chemokine CCL5 - administration & dosage; Chemokine CCL5 - physiology; Cytokines - biosynthesis; Epitopes - administration & dosage; Epitopes - immunology; Epitopes, T-Lymphocyte - immunology; Female; Immunity, Mucosal - immunology; Immunoglobulin A - biosynthesis; Immunoglobulin G - biosynthesis; Immunoglobulin G - blood; Immunoglobulin M - biosynthesis; Immunoglobulin M - blood; Interleukin-12; Interphase - immunology; Intestinal Mucosa - immunology; Intestinal Mucosa - metabolism; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Nasal Mucosa - immunology; Nasal Mucosa - metabolism; Ovalbumin - administration & dosage; Ovalbumin - immunology; RANTES; Receptors, Interleukin - biosynthesis; Receptors, Interleukin-12; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism

RANTES is produced by lymphoid and epithelial cells of the mucosa in response to various external stimuli and is chemotactic for lymphocytes. The role of RANTES in adaptive mucosal immunity has not been studied. To better elucidate the role of this chemokine, we have characterized the effects of RAN...