Brainstem glucose metabolism predicts reward dependence scores in treatment-resistant major depression

• Published in: Psychological medicine Vol. 52; no. 14; pp. 3260 - 3266
• Main Authors: Wu, Guo-Rong, Baeken, Chris
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.10.2022
• Subjects: Antidepressants; Brain research; Brain stem; Brain Stem - diagnostic imaging; Character; Depression; Depressive Disorder, Major - diagnostic imaging; Depressive Disorder, Major - drug therapy; Dopamine receptors; Fluorodeoxyglucose F18; Gender; Glucose; Glucose metabolism; Humans; Individual differences; Locus coeruleus; Medical imaging; Mental depression; Metabolism; Neurobiology; Neuroimaging; Neurosciences; Novelty seeking; Original; Original Article; Personality; Personality Inventory; Personality tests; Personality traits; Pontine nuclei; Positron emission tomography; Refractory depression; Reinforcement; Reticular formation; Reward; Temperament; Temperament - physiology; Tomography; Treatment resistance; Ventral tegmentum; 18FDG PET; reward dependence; depression; TCI; treatment resistance

It has been suggested that individual differences in temperament could be involved in the (non-)response to antidepressant (AD) treatment. However, how neurobiological processes such as brain glucose metabolism may relate to personality features in the treatment-resistant depressed (TRD) state remai...