Development and Validation of a Nine-Redox-Related Long Noncoding RNA Signature in Renal Clear Cell Carcinoma

• Published in: Oxidative medicine and cellular longevity Vol. 2020; no. 2020; pp. 1 - 30
• Main Authors: Wang, Shao-Gang, Sun, Jian-Xuan, Liu, Chen-Qian, Lu, Jun-Lin, Yang, Xun, Qi-Dong, Xia, Li, Cong
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc
• Subjects: Aged; Apoptosis; Biomarkers; Biomarkers, Tumor - metabolism; Calibration; Cancer therapies; Carcinoma, Renal Cell - metabolism; Carcinoma, Renal Cell - mortality; Cell Survival; Disease; Female; Gene Expression Profiling - methods; Gene Expression Regulation, Neoplastic; Genes; Genome, Human; Homeostasis; Humans; Kaplan-Meier Estimate; Kidney cancer; Kidney Neoplasms - metabolism; Kidney Neoplasms - mortality; Male; Medical prognosis; Metastasis; Middle Aged; Nomograms; Oxidation; Oxidation-Reduction; Prognosis; Regression Analysis; Risk; RNA, Long Noncoding - metabolism; ROC Curve; Survival analysis; Transcriptome; Treatment Outcome

Background. Redox plays an essential role in the pathogeneses and progression of tumors, which could be regulated by long noncoding RNA (lncRNA). We aimed to develop and verify a novel redox-related lncRNA-based prognostic signature for clear cell renal cell carcinoma (ccRCC). Materials and Methods....