A Pilot Study on Blood Components in COVID-19 Affected Subjects: A Correlation to UPR Signalling and ER-Stress

• Published in: Indian journal of clinical biochemistry Vol. 38; no. 3; pp. 374 - 384
• Main Authors: Bansal, Akash, Kumar, Sushil, Rai, Neha, Kumari, Shilpi, Kumar, Visesh, Kumar, Ajeet, Chandra, Nimai Chand
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01.07.2023; Springer; Springer Nature B.V
• Subjects: Acute respiratory distress syndrome; Biochemistry; Biomedical and Life Sciences; Blood pressure; Cells; Cellular stress response; Chemistry/Food Science; Coronaviruses; COVID-19; Cytokines; Development and progression; Endoplasmic reticulum; Health aspects; Hemoglobin; Homeostasis; Immune response; Immunoglobulin G; Infection; Infections; Leukocytes; Life Sciences; Lymphocytes; Mammalian cells; Microbiology; Original Research Article; Pathology; Protein biosynthesis; Protein folding; Respiratory distress syndrome; Severe acute respiratory syndrome coronavirus 2; Signal transduction; TRAF2 protein; COVID-19; Protein misfolding; ER-stress; IgG response; TRAF2; PERK; Unfolded protein response

The endoplasmic reticulum (ER) is the site for protein synthesis, its folding and secretion. An intricate set of signalling pathways, called UPR pathways, have been evolved by ER in mammalian cells, to allow the cell to respond the presence of misfolded proteins within the ER. Breaching of these sig...