Relationship between Decreased Serum Superoxide Dismutase Activity and Metabolic Syndrome: Synergistic Mediating Role of Insulin Resistance and β-Cell Dysfunction

• Published in: Oxidative medicine and cellular longevity Vol. 2020; no. 2020; pp. 1 - 10
• Main Authors: Li, Wei, Xu, Lingling, Li, Yu-xiu, Ping, Fan, Zeng, Jingbo, He, Shuli, Ma, Chunxiao, Li, Pingping, Lv, Lu, Ma, Chifa, Liu, Yiwen, Zhang, Huabing
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc
• Subjects: Adult; Age; Aged; Aged, 80 and over; Aging; Biomarkers - metabolism; Blood pressure; Calories; Cellular Senescence; Cholesterol; Data collection; Diet; Female; Glucose; Glutathione; Humans; Hypertension; Inflammation - pathology; Insulin Resistance; Insulin-Secreting Cells - pathology; Lipids; Logistic Models; Male; Males; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - metabolism; Metabolomics; Middle Aged; Mitochondrial DNA; Multivariate Analysis; Oxidative Stress; Pathogenesis; Risk Factors; Software; Studies; Superoxide Dismutase - blood; Triglycerides - metabolism; Variables; Variance analysis; Vitamins; Young Adult; United States > US; China

The interplays of cellular aging and oxidative stress (OS) markers form a complex network, which has been reported to be interrelated with numerous age-related and metabolic diseases, including metabolic syndrome (MS). However, given the multifactorial mechanisms of MS, several important confounders...