Zebrafish as a pharmacological tool: the how, why and when

Zebrafish combine the relevance of a vertebrate with the scalability of an invertebrate. They can live in 96-well plate format and readily absorb chemicals from the water. These features have stimulated the use of zebrafish by medical researchers to model human disease and then assess the action of...

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Bibliographic Details
Published inCurrent opinion in pharmacology Vol. 4; no. 5; pp. 504 - 512
Main Author Goldsmith, Paul
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2004
Subjects
Animals
Disease Models, Animal
Drug Evaluation, Preclinical - methods
Mammals - physiology
Species Specificity
Zebrafish - embryology
Zebrafish - genetics
Zebrafish - physiology
ARMD
HERG
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Summary:Zebrafish combine the relevance of a vertebrate with the scalability of an invertebrate. They can live in 96-well plate format and readily absorb chemicals from the water. These features have stimulated the use of zebrafish by medical researchers to model human disease and then assess the action of compounds in a whole organism. Examples of the power of this system have been illustrated with the cloning of zebrafish human ether-a-go-go-related gene (HERG), which shows near 100% homology in key domains, and the associated ability to identify drugs that prolong the QT interval both rapidly and with tiny amounts (micrograms) of compound.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
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ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2004.04.005