DNA methylation and sex-specific expression of FKBP5 as correlates of one-month bedtime cortisol levels in healthy individuals

• Published in: Psychoneuroendocrinology Vol. 97; pp. 164 - 173
• Main Authors: Lee, Richard S., Mahon, Pamela B., Zandi, Peter P., McCaul, Mary E., Yang, Xiaoju, Bali, Utsav, Wand, Gary S.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2018
• Subjects: Adult; Allostatic; Biomarkers - blood; Circadian Rhythm; Cortisol; DNA methylation; DNA Methylation - genetics; Female; FKBP5; Gene expression; Gene Expression - genetics; Gene Expression Profiling; Genotype; Healthy Volunteers; Humans; Hydrocortisone - analysis; Hydrocortisone - genetics; Load; Male; Middle Aged; Polymorphism, Single Nucleotide - genetics; Psychometrics; Saliva - chemistry; Sex Factors; Stress; Tacrolimus Binding Proteins - analysis; Tacrolimus Binding Proteins - genetics; Load; Allostatic; DNA methylation; Cortisol; Gene expression; Stress; FKBP5

•75 healthy subjects recruited to obtain 30+ consecutive days of awakening and bedtime saliva cortisol and psychometric measures.•Blood collected at the end of the 30 days to assess gene expression, DNA methylation, and genotypes.•Significant correlation observed between mean 30-day awakening and be...