The Role of Dendritic Brain-Derived Neurotrophic Factor Transcripts on Altered Inhibitory Circuitry in Depression

• Published in: Biological psychiatry (1969) Vol. 85; no. 6; pp. 517 - 526
• Main Authors: Oh, Hyunjung, Piantadosi, Sean C., Rocco, Brad R., Lewis, David A., Watkins, Simon C., Sibille, Etienne
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.03.2019
• Subjects: Animals; Atrophy - pathology; BDNF; Behavior, Animal; Brain-Derived Neurotrophic Factor - biosynthesis; Brain-Derived Neurotrophic Factor - drug effects; Case-Control Studies; Dendrite; Dendrites - metabolism; Dendrites - pathology; Depressive Disorder, Major - metabolism; Down-Regulation; Female; GABA; Gene Expression - drug effects; Gene Knockdown Techniques; Humans; Major depressive disorder; Male; Mice; Prefrontal Cortex - metabolism; Primary Cell Culture; Pyramidal Cells - metabolism; RNA, Small Interfering - pharmacology; Somatostatin - biosynthesis; SST; Stress; Stress, Psychological - metabolism; GABA; BDNF; SST; Major depressive disorder; Stress; Dendrite

A parallel downregulation of brain-derived neurotrophic factor (BDNF) and somatostatin (SST), a marker of inhibitory gamma-aminobutyric acid interneurons that target pyramidal cell dendrites, has been reported in several brain areas of subjects with major depressive disorder (MDD). Rodent genetic st...