Antidiabetic effects of extracts from Psidium guajava

• Published in: Journal of ethnopharmacology Vol. 96; no. 3; pp. 411 - 415
• Main Authors: Oh, Won Keun, Lee, Chul Ho, Lee, Myung Sun, Bae, Eun Young, Sohn, Cheon Bae, Oh, Hyuncheol, Kim, Bo Yeon, Ahn, Jong Seog
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 15.01.2005; Elsevier
• Subjects: Age Factors; animal disease models; Animals; Biological and medical sciences; Blood glucose; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Disease Models, Animal; enzyme inhibitors; Fatty Liver - complications; Fatty Liver - drug therapy; Fatty Liver - pathology; Female; General pharmacology; glycemic effect; Hypoglycemic Agents - therapeutic use; Injections, Intraperitoneal; leaves; Leprdb/ Leprdb mice; Male; Medical sciences; medicinal plants; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; noninsulin-dependent diabetes mellitus; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; phosphoric monoester hydrolases; Phytotherapy; plant extracts; Plant Extracts - chemistry; Plant Extracts - therapeutic use; Plant Leaves - chemistry; protein-tyrosine-phosphatase1B; Psidium; Psidium guajava; PTP1B; Type 2 diabetes; EtOAc; PBS; Type 2 diabetes; Blood glucose; PAS; DTT; IDDM; IR; i.p; Lepr db / Lepr db mice; p-NPP; PTP1B; MeOH; Psidium guajava; NIDDM; Endocrinopathy; Biological fluid; Pharmacognosy; Rodentia; Metabolic diseases; Extract; Glucose; Blood; Medicinal plant; Vertebrata; Hypoglycemic agent; Mammalia; Mouse; Dicotyledones; Animal; Angiospermae; Plant origin; Leprdb/Leprdb mice; Myrtaceae; Spermatophyta

During a screening of medicinal plants for inhibition of protein tyrosine phosphatase1B (PTP1B), an extract from Psidium guajava (Myrtaceae) leaves exhibited significant inhibitory effect on PTP1B. Thus, its antidiabetic effect on Lepr db / Lepr db mice was evaluated. Significant blood glucose lower...