Exposure to cold impairs interferon-induced antiviral defense

• Published in: Archives of virology Vol. 162; no. 8; pp. 2231 - 2237
• Main Authors: Boonarkart, Chompunuch, Suptawiwat, Ornpreya, Sakorn, Kittima, Puthavathana, Pilaipan, Auewarakul, Prasert
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.08.2017; Springer Nature B.V
• Subjects: 2',5'-Oligoadenylate Synthetase - metabolism; Antiviral Agents - pharmacology; Antiviral drugs; Biomedical and Life Sciences; Biomedicine; Cell lines; cold; Cold Temperature - adverse effects; HEK293 Cells; Humans; Infections; Infectious Diseases; Influenza; Influenza A virus - drug effects; Influenza A virus - pathogenicity; Influenza A virus - physiology; Influenza, Human - virology; Interferon; interferon-beta; Interferon-beta - pharmacology; Medical Microbiology; messenger RNA; Myxovirus resistance proteins; Myxovirus Resistance Proteins - metabolism; Original Article; Orthomyxoviridae; Replication; respiratory system; Respiratory tract; temperature; Temperature effects; Viral infections; Virology; virus replication; Virus Replication - drug effects; viruses; Influenza Virus; Avian Influenza Virus; Antiviral Defense; MDCK Cell; Rhinovirus Infection

It is commonly believed that exposure to low temperature increases susceptibility to viral infection in the human respiratory tract, but a molecular mechanism supporting this belief has yet to be discovered. In this study, we investigated the effect of low temperature on viral infection and innate d...