SPARC Promotes Cathepsin B-Mediated Melanoma Invasiveness through a Collagen I/α2β1 Integrin Axis

• Published in: Journal of investigative dermatology Vol. 131; no. 12; pp. 2438 - 2447
• Main Authors: Girotti, María R., Fernández, Marisol, López, Juan A., Camafeita, Emilio, Fernández, Elmer A., Albar, Juan P., Benedetti, Lorena G., Valacco, María P., Brekken, Rolf A., Podhajcer, Osvaldo L., Llera, Andrea S.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2011; Nature Publishing Group
• Subjects: Biological and medical sciences; Cadherins - metabolism; Cathepsin B - metabolism; Cell Line, Tumor; Collagen Type I - metabolism; Cytokines - metabolism; Dermatology; Down-Regulation; Epithelial-Mesenchymal Transition; Gene Expression Profiling; Humans; Integrin alpha2beta1 - metabolism; Medical sciences; Melanoma - metabolism; Melanoma - pathology; Neoplasm Invasiveness; Neoplasm Proteins - metabolism; Osteonectin - metabolism; Skin Neoplasms - metabolism; Skin Neoplasms - pathology; Transforming Growth Factor beta1 - metabolism; Tumors of the skin and soft tissue. Premalignant lesions; Integrin; Malignant tumor; Dermatology; Collagen; Malignant melanoma; Cancer

In melanoma, the extracellular protein SPARC (secreted protein acidic and rich in cysteine) is related to tumor progression. Some of the evidence that links SPARC to melanoma progression indicates that SPARC may be involved in the acquisition of mesenchymal traits that favor metastatic dissemination...