Hepcidin Is Down-Regulated in Alcohol Loading

• Published in: Alcoholism, clinical and experimental research Vol. 31; no. s1; pp. S2 - S8
• Main Authors: Ohtake, Takaaki, Saito, Hiroyuki, Hosoki, Yayoi, Inoue, Mitsutaka, Miyoshi, Shigeki, Suzuki, Yasuaki, Fujimoto, Yoshinori, Kohgo, Yutaka
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.01.2007
• Subjects: Alcoholic Liver Disease; Animals; Antimicrobial Cationic Peptides - blood; Antimicrobial Cationic Peptides - genetics; Down-Regulation - genetics; Ethanol; Ferritins - blood; Hemosiderosis - blood; Hemosiderosis - genetics; Hemosiderosis - pathology; Hepcidin; Hepcidins; Humans; Intestinal Absorption - genetics; Iron; Iron - blood; Iron Overload - blood; Iron Overload - genetics; Iron Overload - pathology; Liver - metabolism; Liver Diseases, Alcoholic - blood; Liver Diseases, Alcoholic - genetics; Liver Diseases, Alcoholic - pathology; Macrophages - metabolism; Male; Mice; Mice, Inbred C57BL; Protein Precursors - genetics; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics

Background: It is common for alcoholic patients to have excess iron accumulation in the liver, which may contribute to the development of alcoholic liver disease (ALD). However, the mechanism of hepatic iron uptake in ALD is still obscure. Recently, a novel iron‐regulatory hormone hepcidin was found...