Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer’s Disease

• Published in: Frontiers in cellular neuroscience Vol. 13; p. 339
• Main Authors: Zhang, Yuan, Zhao, Yanfang, Zhang, Lei, Yu, Wanpeng, Wang, Yu, Chang, Wenguang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 30.07.2019; Frontiers Media S.A
• Subjects: Alzheimer's disease; amyloid-β; Binding sites; Brain; cellular prion protein; Cognitive ability; Disease; Hypotheses; Neurofibrillary tangles; Neuroscience; Neurotoxicity; oligomers; Pathogenesis; Pathology; Prion protein; Proteins; receptor; Senile plaques; Tau protein; China; amyloid-β; receptor; Alzheimer’s disease; cellular prion protein; oligomers

The pathological features of Alzheimer's disease (AD) include senile plaques induced by amyloid-β (Aβ) protein deposits, neurofibrillary tangles formed by aggregates of hyperphosphorylated tau proteins and neuronal cell loss in specific position within the brain. Recent observations have sugges...