Higher infectivity of the SARS‐CoV‐2 new variants is associated with K417N/T, E484K, and N501Y mutants: An insight from structural data - Khan, Abbas; Zia, Tauqir; Suleman, Muhammad; Khan, Taimoor; Ali, Syed Shujait; Abbasi, Aamir Ali; Mohammad, Anwar; Wei, Dong‐Qing (Journal of cellular physiology, 2021)
Keywords: ACE2; Angiotensin-converting enzyme 2; Angiotensin-Converting Enzyme 2 - metabolism; Binding; Brazil; COVID-19; COVID-19 - metabolism; Dynamic structural analysis; Epistasis; Evolution; Free energy; Glycoproteins; Humans; In vivo methods and tests; Infectivity; KD (dissociation constant); MD simulation; Mutants; Mutation; Mutation - genetics; new variants; Pathogenicity; Pathogens; Protein Binding - genetics; Proteins; protein–protein docking; Receptors; SARS-CoV-2 - genetics; SARS‐CoV‐2; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; South Africa; Spike glycoprotein; Spike protein; United Kingdom; Virulence; Virulence - genetics; Brazil; South Africa; United Kingdom; United Kingdom--UK; MD simulation; new variants; SARS-CoV-2; protein-protein docking; KD (dissociation constant)