The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

• Published in: Endocrine reviews Vol. 29; no. 3; pp. 317 - 333
• Main Authors: Scheuner, Donalyn, Kaufman, Randal J
• Format: Journal Article
• Language: English
• Published: United States Endocrine Society 01.05.2008; Copyright by The Endocrine Society; The Endocrine Society
• Subjects: Animals; Apoptosis - physiology; Diabetes Mellitus - metabolism; Endoplasmic Reticulum - chemistry; Endoplasmic Reticulum - metabolism; Humans; Insulin - metabolism; Insulin-Secreting Cells - metabolism; Protein Folding; Signal Transduction - physiology

The endoplasmic reticulum (ER) is the entry site into the secretory pathway for newly synthesized proteins destined for the cell surface or released into the extracellular milieu. The study of protein folding and trafficking within the ER is an extremely active area of research that has provided nov...