Expression of mitotic checkpoint proteins BUB1B and MAD2L1 in salivary duct carcinomas

• Published in: Journal of oral pathology & medicine Vol. 39; no. 4; pp. 349 - 355
• Main Authors: Ko, Young Hyeh, Roh, Ji Hyeon, Son, Young-Ik, Chung, Man Ki, Jang, Jeon Yeob, Byun, Hayoung, Baek, Chung-Hwan, Jeong, Han-Sin
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2010
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - analysis; BUB1B; Calcium-Binding Proteins - analysis; Carcinoma - pathology; Carcinoma - secondary; Cell Cycle Proteins - analysis; Cohort Studies; Disease-Free Survival; Female; Gene Expression Regulation, Neoplastic - genetics; Humans; Mad2 Proteins; MAD2L1; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; prognosis; Proportional Hazards Models; Protein-Serine-Threonine Kinases - analysis; Proto-Oncogene Proteins - analysis; Receptor, Epidermal Growth Factor - analysis; Receptor, ErbB-2 - analysis; Receptors, Androgen - analysis; Remission Induction; Repressor Proteins - analysis; salivary duct carcinomas; Salivary Ducts - pathology; salivary gland neoplasm; Salivary Gland Neoplasms - pathology; Survival Rate; Transforming Growth Factor beta - analysis; Treatment Outcome; Vascular Endothelial Growth Factor A - analysis

J Oral Pathol Med (2010) 39: 349–355 Objective:  Defects in the mitotic checkpoint lead to aneuploidy and might facilitate tumorigenesis. However, the ploidy status in salivary duct carcinoma (SDC) has been reported to play limited role in prediction of prognosis. Thus, we need more reliable markers...