Hepatic fibrosis plays a central role in the pathogenesis of thrombocytopenia in patients with chronic viral hepatitis

• Published in: British journal of haematology Vol. 113; no. 3; pp. 590 - 595
• Main Authors: Adinolfi, Luigi Elio, Giordano, Maria Grazia, Andreana, Augusto, Tripodi, Marie‐Francoise, Utili, Riccardo, Cesaro, Giuseppe, Ragone, Enrico, Mangoni, Emanuele Durante, Ruggiero, Giuseppe
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science, Ltd 01.06.2001; Blackwell; Blackwell Publishing Ltd
• Subjects: Adult; Aged; Autoantibodies - analysis; Biological and medical sciences; Blood Platelets - immunology; Chronic Disease; chronic viral hepatitis; Esophageal and Gastric Varices - blood; Esophageal and Gastric Varices - complications; Esophageal and Gastric Varices - pathology; Female; Hematology; hepatic fibrosis; Hepatitis, Viral, Human - blood; Hepatitis, Viral, Human - complications; Hepatitis, Viral, Human - pathology; Human viral diseases; Humans; Infectious diseases; Liver - pathology; Liver Cirrhosis - blood; Liver Cirrhosis - complications; Liver Cirrhosis - pathology; Male; Medical sciences; Middle Aged; Platelet Count; Splenomegaly; thrombocytopenia; Thrombocytopenia - blood; Thrombocytopenia - etiology; Thrombocytopenia - pathology; thrombopoietin; Thrombopoietin - analysis; Viral diseases; Viral hepatitis; Human; Thrombocytopenia; Portal circulation disease; Pathogenesis; Liver; Cardiovascular disease; Hepatic disease; Hemopathy; Thrombopoietin; Infection; Vascular disease; Chronic; Viral hepatitis; Platelet; Viral disease; Fibrosis; Portal hypertension; Digestive diseases; Complication; Growth factor

The pathogenesis of thrombocytopenia in chronic hepatitis is not well known. This study evaluated the relationship between liver injury, serum thrombopoietin, splenomegaly and thrombocytopenia in chronic viral hepatitis. Two hundred and nine patients were enrolled, 85 with splenomegaly and 124 witho...