NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery

• Published in: Journal of leukocyte biology Vol. 97; no. 3; pp. 583 - 598
• Main Authors: Spada, Roberto, Rojas, Jose´ M., Pe´rez‐Yagu¨e, Sonia, Mulens, Vladimir, Cannata‐Ortiz, Pablo, Bragado, Rafael, Barber, Domingo F.
• Format: Journal Article
• Language: English
• Published: United States Society for Leukocyte Biology 01.03.2015
• Subjects: Adult; Aged; Animals; Antigens, Ly - metabolism; Biomarkers - metabolism; Carrier Proteins - metabolism; Cell Differentiation - immunology; Eomes; Female; Histocompatibility Antigens Class I - metabolism; Host Defense & Pathophysiology; Humans; Interferon-gamma - biosynthesis; Kidney - immunology; Kidney - pathology; Kidney Glomerulus - metabolism; Kidney Glomerulus - pathology; Killer Cells, Natural - immunology; Ligands; Lupus Nephritis - immunology; Lupus Nephritis - pathology; Male; MICA; Mice, Inbred MRL lpr; Middle Aged; MRL/lpr; MRL/MpJ; Natural Cytotoxicity Triggering Receptor 1 - metabolism; Nuclear Matrix-Associated Proteins - metabolism; Nucleocytoplasmic Transport Proteins - metabolism; Phenotype; Phosphorylation; Rae; Spleen - pathology; STAT5 Transcription Factor - metabolism; T-Box Domain Proteins - metabolism; T‐bet; Young Adult; Eomes; MRL/lpr; MRL/MpJ; T-bet; MICA; Rae

NKG2D ligand expression, NK cells, and cytokine expression by NK cells could play a role in the lupus nephritic process. NK cells are a major component of the immune system, and alterations in their activity are correlated with various autoimmune diseases. In the present work, we observed an increas...