Decreased plasma tissue factor pathway inhibitor in women taking combined oral contraceptives

• Published in: American journal of hematology Vol. 60; no. 3; pp. 175 - 180
• Main Authors: Harris, Geoffrey M., Stendt, Caroline L., Vollenhoven, Beverley J., Gan, T. Eng, Tipping, Peter G.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.03.1999; Wiley-Liss
• Subjects: Adolescent; Adult; Biological and medical sciences; Blood Coagulation - drug effects; Cholesterol, LDL - blood; coagulation; Contraceptives, Oral, Combined - adverse effects; Down-Regulation; Drug toxicity and drugs side effects treatment; factor VIIa; Factor VIIa - metabolism; Female; Fibrinogen - metabolism; Fibrinolytic Agents - blood; Humans; lipoprotein; Lipoproteins - blood; Medical sciences; Middle Aged; oral contraceptive; Peptide Fragments - metabolism; Pharmacology. Drug treatments; Protein Precursors - metabolism; prothrombin; Prothrombin - metabolism; thrombosis; Thrombosis - blood; Thrombosis - etiology; tissue factor pathway inhibitor; Toxicity: cardiovascular system; von Willebrand Factor - metabolism; Blood coagulation; Kunitz inhibitor; Steroid hormone; Toxicity; Oral administration; Cardiovascular disease; Activation; Thrombosis; Vascular disease; Estroprogestagen; Extrinsic pathway; Risk factor; Contraceptive; Tissue factor pathway inhibitor; Women; Hemic System; Risk Factors; Thrombosis > women; Biology; Contraception; Family Planning; Research Methodology; Embolism; Diseases; Oceania; Blood Coagulation Effects > women; Developed Countries; Oral Contraceptives, Combined; Clinical Research; Hematological Effects; Vascular Diseases; Contraceptive Methods; Research Report; Physiology; Oral Contraceptives; Australia; Thromboembolism

Use of combined oral contraceptives (OC) is associated with a significant risk of thrombosis. The mechanisms of this effect are not clearly defined. Tissue factor pathway inhibitor (TFPI) is a circulating anti‐coagulant that inhibits the earliest steps in activation of the extrinsic coagulation path...