Transcription Factor RUNX1 Regulates Platelet PCTP (Phosphatidylcholine Transfer Protein): Implications for Cardiovascular Events: Differential Effects of RUNX1 Variants

• Published in: Circulation (New York, N.Y.) Vol. 136; no. 10; pp. 927 - 939
• Main Authors: Mao, Guangfen, Songdej, Natthapol, Voora, Deepak, Goldfinger, Lawrence E., Del Carpio-Cano, Fabiola E., Myers, Rachel A., Rao, A. Koneti
• Format: Journal Article
• Language: English
• Published: United States by the American College of Cardiology Foundation and the American Heart Association, Inc 05.09.2017
• Subjects: Blood Platelets - metabolism; Cell Line, Tumor; Cohort Studies; Computational Biology; Core Binding Factor Alpha 2 Subunit - genetics; Humans; Immunoblotting - methods; Muramidase; Peptide Fragments; Phospholipid Transfer Proteins - genetics; Phospholipid Transfer Proteins - metabolism; Transcription Factors - genetics; Transfection; RUNX1 protein, human; blood platelets; cardiovascular diseases; phospholipid transfer proteins

BACKGROUND:PCTP (phosphatidylcholine transfer protein) regulates the intermembrane transfer of phosphatidylcholine. Higher platelet PCTP expression is associated with increased platelet responses on activation of protease-activated receptor 4 thrombin receptors noted in black subjects compared with...