Classical and noncanonical functions of miRNAs in cancers

• Published in: Trends in genetics Vol. 38; no. 4; pp. 379 - 394
• Main Authors: Dragomir, Mihnea P., Knutsen, Erik, Calin, George A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2022; Elsevier
• Subjects: cancer; Epigenesis, Genetic - genetics; Gene Expression; germline and somatic mutations; Humans; MicroRNAs - genetics; miRNA; miRNA mimicry; Neoplasms - genetics; non-canonical functions; pri- and pre-miRNA regulation; germline and somatic mutations; miRNA mimicry; miRNA; cancer; non-canonical functions; pri- and pre-miRNA regulation

Alterations in microRNAs (miRNAs) expression are causative in the initiation and progression of human cancers. The molecular events responsible for the widespread differential expression of miRNAs in malignancy are exemplified by their location in cancer-associated genomic regions, epigenetic mechan...