Cancer cell-derived immunoglobulin G activates platelets by binding to platelet FcγRIIa

• Published in: Cell death & disease Vol. 10; no. 2; p. 87
• Main Authors: Miao, Shuo, Shu, Dan, Zhu, Ying, Lu, Meng, Zhang, Qingsong, Pei, Youliang, He, Ao-Di, Ma, Rong, Zhang, Bixiang, Ming, Zhang-Yin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.01.2019; Springer Nature B.V
• Subjects: 13/1; 13/109; 13/21; 13/31; 13/95; 38/1; 631/67; 692/699/1541; 692/699/67/2195; Antibodies; Biochemistry; Biomedical and Life Sciences; Blood Platelets - metabolism; Cancer; Case-Control Studies; Cell Biology; Cell Culture; Cell Line, Tumor; Flow cytometry; Humans; Immunofluorescence; Immunoglobulin G; Immunoglobulin G - blood; Immunology; Immunoprecipitation; Life Sciences; Liver cancer; Neoplasms - blood; Neoplasms - immunology; PAC1 protein; Platelet Activation; Platelet aggregation; Receptors, IgG - metabolism; Signal Transduction; Syk protein; Thrombosis; Tumors

Tumor-associated thrombosis is the second leading risk factor for cancer patient death, and platelets activity is abnormal in cancer patients. Discovering the mechanism of platelet activation and providing effective targets for therapy are urgently needed. Cancer cell- derived IgG has been reported...