Assessment of Human Pancreatic Islet Architecture and Composition by Laser Scanning Confocal Microscopy

• Published in: The journal of histochemistry and cytochemistry Vol. 53; no. 9; pp. 1087 - 1097
• Main Authors: Brissova, Marcela, Fowler, Michael J, Nicholson, Wendell E, Chu, Anita, Hirshberg, Boaz, Harlan, David M, Powers, Alvin C
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA Histochemical Soc 01.09.2005; SAGE Publications
• Subjects: Animals; Humans; Immunohistochemistry; In Vitro Techniques; Insulin - metabolism; Insulin Secretion; Islets of Langerhans - cytology; Islets of Langerhans - metabolism; Macaca mulatta; Mice; Microscopy, Confocal; Species Specificity; confocal microscopy; composition; pancreatic islets; architecture

The recent success of pancreatic islet transplantation has generated considerable enthusiasm. To better understand the quality and characteristics of human islets used for transplantation, we performed detailed analysis of islet architecture and composition using confocal laser scanning microscopy....