Exploring the potential of the TCR repertoire as a tumor biomarker (Review)

• Published in: Oncology letters Vol. 28; no. 3; p. 413
• Main Authors: Huang, An-Li, He, Yan-Zhao, Yang, Yong, Pang, Min, Zheng, Guo-Ping, Wang, Hai-Long
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.09.2024; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Accuracy; Antigens; Biomarkers; Cancer; Cell death; Entropy; Genes; Immune system; Immunotherapy; Ligands; Liver cancer; Lymphocytes; Oncology, Experimental; Pathogens; Peptides; Prostate cancer; Proteins; Review; T cell receptors; T cells; Tumors; tumor diagnosis; biomarker; tumor immunotherapy; TCR repertoire; tumor prognosis
• ISSN: 1792-1074; 1792-1082
• DOI: 10.3892/ol.2024.14546

T cells play an important role in adaptive immunity. Mature T cells specifically recognize antigens on major histocompatibility complex molecules through T-cell receptors (TCRs). As the TCR repertoire is highly diverse, its analysis is vital in the assessment of T cells. Advances in sequencing technology have provided convenient methods for further investigation of the TCR repertoire. In the present review, the TCR structure and the mechanisms by which TCRs function in tumor recognition are described. In addition, the potential value of the TCR repertoire in tumor diagnosis is reviewed. Furthermore, the role of the TCR repertoire in tumor immunotherapy is introduced, and the relationships between the TCR repertoire and the effects of different tumor immunotherapies are discussed. Based on the reviewed literature, it may be concluded that the TCR repertoire has the potential to serve as a biomarker for tumor prognosis. However, a wider range of cancer types and more diverse subjects require evaluation in future research to establish the TCR repertoire as a biomarker of tumor immunity.