Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development

• Published in: Translational psychiatry Vol. 8; no. 1; pp. 230 - 10
• Main Authors: McPhie, Donna L., Nehme, Ralda, Ravichandran, Caitlin, Babb, Suzann M., Ghosh, Sulagna Dia, Staskus, Alexandra, Kalinowski, Amy, Kaur, Rupinderjit, Douvaras, Panagiotis, Du, Fei, Ongur, Dost, Fossati, Valentina, Eggan, Kevin, Cohen, Bruce M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.10.2018; Nature Publishing Group
• Subjects: 13; 13/1; 13/100; 13/106; 13/31; 13/51; 14/1; 14/63; 38/39; 38/91; 631/378/340; 631/532; Adult; Behavioral Sciences; Biological Psychology; Brain - pathology; Cell Differentiation; Cell Line; Female; Humans; Hypotheses; Induced Pluripotent Stem Cells - physiology; Magnetic Resonance Imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Myelin Sheath - pathology; Neurosciences; Oligodendrocyte Precursor Cells - physiology; Oligodendroglia - physiology; Pharmacotherapy; Psychiatry; Schizophrenia - pathology; Schizophrenia - physiopathology; Signal transduction; White Matter; Young Adult

Abnormalities of brain connectivity and signal transduction are consistently observed in individuals with schizophrenias (SZ). Underlying these anomalies, convergent in vivo, post mortem, and genomic evidence suggest abnormal oligodendrocyte (OL) development and function and lower myelination in SZ....