The effect of moderate weight loss, with or without (1, 3)(1, 6)-β-glucan addition, on subcutaneous adipose tissue inflammatory gene expression in young subjects with uncomplicated obesity

• Published in: Endocrine Vol. 61; no. 2; pp. 275 - 284
• Main Authors: Strączkowski, Marek, Nikołajuk, Agnieszka, Majewski, Radosław, Filarski, Remigiusz, Stefanowicz, Magdalena, Matulewicz, Natalia, Karczewska-Kupczewska, Monika
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2018; Springer Nature B.V
• Subjects: Adipose tissue; Adult; beta-Glucans - administration & dosage; beta-Glucans - pharmacology; Biopsy; Body weight loss; Caloric Restriction; Diabetes; Endocrinology; Female; Gelatinase B; Gene expression; Gene Expression - drug effects; Humanities and Social Sciences; Humans; Hypocaloric diet; Immunomodulation; Inflammation; Inflammation - complications; Inflammation - genetics; Inflammation - metabolism; Inflammation - pathology; Insulin; Insulin resistance; Insulin Resistance - genetics; Interleukin 1; Interleukin 18; Interleukin 6; Interleukin 6 receptors; Internal Medicine; Janus kinase; Janus kinase 2; Male; Medicine; Medicine & Public Health; Monocyte chemoattractant protein 1; multidisciplinary; Nutrient deficiency; Obesity; Obesity - complications; Obesity - diet therapy; Obesity - genetics; Obesity - pathology; Original; Original Article; Science; Stat3 protein; Subcutaneous Fat - drug effects; Subcutaneous Fat - metabolism; Subcutaneous Fat - pathology; Weight control; Weight Loss - physiology; Young Adult; β-Glucan; Obesity; Inflammation; Low-calorie diet; Insulin sensitivity; (1, 3)(1, 6)-β-glucan

Purpose Obesity is characterized by insulin resistance and low-grade systemic and adipose tissue (AT) inflammation. It remains unclear whether beneficial effects of weight loss are related to AT inflammation. We aimed to assess the effect of weight loss during low-calorie diet on insulin sensitivity...