A glutamate receptor-interacting protein homolog organizes muscle guidance in Drosophila

• Published in: Genes & development Vol. 18; no. 2; pp. 223 - 237
• Main Authors: Swan, Laura E, Wichmann, Carolin, Prange, Ulrike, Schmid, Andreas, Schmidt, Manuela, Schwarz, Tobias, Ponimaskin, Evgeni, Madeo, Frank, Vorbrüggen, Gerd, Sigrist, Stephan J
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 15.01.2004
• Subjects: Animals; Carrier Proteins - metabolism; Cell Differentiation - physiology; Drosophila; Drosophila - embryology; Drosophila - metabolism; Drosophila Proteins; glutamate receptor interacting protein; grip gene; Muscles - abnormalities; Muscles - embryology; Muscles - metabolism; Nerve Tissue Proteins - metabolism; Receptors, AMPA - metabolism; Research Papers

During Drosophila embryogenesis, developing muscles extend growth-cone-like structures to navigate toward specific epidermal attachment sites. Here, we show that the homolog of Glutamate Receptor-Interacting Proteins (DGrip) acts as a key component of proper muscle guidance. Mutations in dgrip impai...