Duodenal Bacteria From Patients With Celiac Disease and Healthy Subjects Distinctly Affect Gluten Breakdown and Immunogenicity

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 151; no. 4; pp. 670 - 683
• Main Authors: Caminero, Alberto, Galipeau, Heather J., McCarville, Justin L., Johnston, Chad W., Bernier, Steve P., Russell, Amy K., Jury, Jennifer, Herran, Alexandra R., Casqueiro, Javier, Tye-Din, Jason A., Surette, Michael G., Magarvey, Nathan A., Schuppan, Detlef, Verdu, Elena F.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2016
• Subjects: Animals; Bacterial Translocation; Case-Control Studies; Celiac Disease; Celiac Disease - genetics; Celiac Disease - immunology; Celiac Disease - microbiology; Duodenum - microbiology; Gastroenterology and Hepatology; Gluten Metabolism; Glutens - immunology; Glutens - metabolism; Humans; Immunogenetic Phenomena; Intestinal Inflammation; Intestinal Microbiota; Lactobacillus - physiology; Mice; Mice, Inbred C57BL; Pseudomonas aeruginosa - physiology; T-Lymphocytes - immunology; CD; LC-MS/MS; Gluten Metabolism; CFU; SFU; TG; Intestinal Microbiota; Intestinal Inflammation; ASF; PT; Celiac Disease; PBMC; transglutaminase; spot-forming units; pepsin-trypsin; liquid chromatography tandem mass spectrometry; altered Schaedler flora; colony-forming unit; peripheral blood mononuclear cell

Partially degraded gluten peptides from cereals trigger celiac disease (CD), an autoimmune enteropathy occurring in genetically susceptible persons. Susceptibility genes are necessary but not sufficient to induce CD, and additional environmental factors related to unfavorable alterations in the micr...