The Role of Glia in Canine Degenerative Myelopathy: Relevance to Human Amyotrophic Lateral Sclerosis

• Published in: Molecular neurobiology Vol. 56; no. 8; pp. 5740 - 5748
• Main Authors: Golubczyk, Dominika, Malysz-Cymborska, Izabela, Kalkowski, Lukasz, Janowski, Miroslaw, Coates, Joan R, Wojtkiewicz, Joanna, Maksymowicz, Wojciech, Walczak, Piotr
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2019; Springer Nature B.V
• Subjects: Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - pathology; Animals; Axons; Biomedical and Life Sciences; Biomedicine; Cell Biology; Central nervous system diseases; Demyelinating Diseases - pathology; Demyelination; Dogs; Energy; Energy metabolism; Female; Histology; Humans; Male; Metabolites; Monocarboxylic Acid Transporters - metabolism; Motor neurons; Motor Neurons - pathology; Myelin; Neurobiology; Neurodegeneration; Neurodegenerative diseases; Neuroglia - pathology; Neurology; Neuronal-glial interactions; Neurosciences; Olig2 protein; Oligodendrocytes; Spinal cord; Spinal Cord - pathology; ALS; Degenerative myelopathy; Monocarboxylate transporters; Demyelination; Disease model

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons and grim prognosis. Over the last decade, studies on neurodegenerative diseases pointed on the role of glia in supporting the proper function of neurons. Particularly,...