Significance of Heme and Heme Degradation in the Pathogenesis of Acute Lung and Inflammatory Disorders

• Published in: International journal of molecular sciences Vol. 22; no. 11; p. 5509
• Main Author: Ryter, Stefan W.
• Format: Journal Article
• Language: English
• Published: MDPI 24.05.2021; MDPI AG
• Subjects: acute lung injury; carbon monoxide; heme; heme oxygenase; inflammation; lung disease; Review

The heme molecule serves as an essential prosthetic group for oxygen transport and storage proteins, as well for cellular metabolic enzyme activities, including those involved in mitochondrial respiration, xenobiotic metabolism, and antioxidant responses. Dysfunction in both heme synthesis and degra...