The efficacy and safety of CAR-T cell therapy in patients with refractory ALL and concomitant HBV infection

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Published inLeukemia Vol. 34; no. 10; pp. 2790 - 2793
Main Authors Lai, Peilong, Chen, Xiaomei, Qin, Le, Jiang, Zhiwu, Luo, Chenwei, Huang, Xin, Wu, Sujing, Ling, Wei, Wang, Yulian, Wang, Jinghua, Deng, Chenxin, Huang, Lisi, Zeng, Lingji, Lu, Zesheng, Zhong, Liye, Liao, Pengjun, Li, Minming, Chen, Dongmei, Geng, Suxia, Wu, Ping, Tang, Zhaoyang, Pei, Duanqing, Du, Xin, Li, Peng, Weng, Jianyu
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.10.2020
Nature Publishing Group
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Audience Academic
Author Pei, Duanqing
Jiang, Zhiwu
Huang, Lisi
Tang, Zhaoyang
Li, Minming
Wu, Sujing
Chen, Xiaomei
Luo, Chenwei
Li, Peng
Geng, Suxia
Wang, Yulian
Zeng, Lingji
Liao, Pengjun
Ling, Wei
Qin, Le
Weng, Jianyu
Wang, Jinghua
Lu, Zesheng
Huang, Xin
Du, Xin
Wu, Ping
Lai, Peilong
Deng, Chenxin
Chen, Dongmei
Zhong, Liye
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  orcidid: 0000-0003-0256-1082
  surname: Lai
  fullname: Lai, Peilong
  organization: Department of Hematology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
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  organization: Department of Hematology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences
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  fullname: Wu, Sujing
  organization: Department of Hematology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences
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  surname: Ling
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  organization: Department of Hematology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences
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  surname: Wang
  fullname: Wang, Yulian
  organization: Department of Hematology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences
– sequence: 10
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  surname: Wang
  fullname: Wang, Jinghua
  organization: Department of Hematology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences
– sequence: 11
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  surname: Deng
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– sequence: 12
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  organization: Department of Hematology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences
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  surname: Zeng
  fullname: Zeng, Lingji
  organization: Department of Hematology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences
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  surname: Lu
  fullname: Lu, Zesheng
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  givenname: Liye
  surname: Zhong
  fullname: Zhong, Liye
  organization: Department of Hematology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences
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  givenname: Pengjun
  surname: Liao
  fullname: Liao, Pengjun
  organization: Department of Hematology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences
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  givenname: Minming
  surname: Li
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  organization: Department of Hematology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences
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  givenname: Dongmei
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  surname: Geng
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  givenname: Ping
  surname: Wu
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  organization: Department of Hematology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences
– sequence: 21
  givenname: Zhaoyang
  surname: Tang
  fullname: Tang, Zhaoyang
  organization: Guangdong Zhaotai InVivo Biomedicine Co. Ltd
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  givenname: Duanqing
  orcidid: 0000-0002-5222-014X
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  orcidid: 0000-0003-2648-9433
  surname: Du
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  email: miyadu@hotmail.com
  organization: Department of Hematology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences
– sequence: 24
  givenname: Peng
  orcidid: 0000-0003-4530-2400
  surname: Li
  fullname: Li, Peng
  email: li_peng@gibh.ac.cn
  organization: State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
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  surname: Weng
  fullname: Weng, Jianyu
  email: wengjianyu1969@163.com
  organization: Department of Hematology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32632097$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_1007_s40278_020_85699_y
crossref_primary_10_3389_fimmu_2022_931452
crossref_primary_10_1007_s44178_024_00082_z
crossref_primary_10_1080_14787210_2021_1855143
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Cites_doi 10.1038/nrclinonc.2017.148
10.1002/hep.29800
10.1056/NEJMoa1709919
10.1038/leu.2017.249
10.1182/blood.2019000888
10.1038/leu.2017.39
10.1186/s13045-018-0572-x
10.1016/S0140-6736(15)61412-X
10.1182/blood.2020004907
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  publication-title: N Engl J Med
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  publication-title: Leukemia
  doi: 10.1038/leu.2017.249
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Animals
Cancer Research
Cell therapy
Critical Care Medicine
Development and progression
Disease Models, Animal
Female
Health aspects
Hematology
Hepatitis B
Hepatitis B - complications
Hepatitis B - diagnosis
Hepatitis B - immunology
Hepatitis B - virology
Hepatitis B virus - immunology
Humans
Immunotherapy, Adoptive - adverse effects
Immunotherapy, Adoptive - methods
Intensive
Internal Medicine
Letter
Lymphocytes
Lymphocytes T
Male
Medicine
Medicine & Public Health
Mice
Middle Aged
Oncology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Receptors, Antigen, T-Cell
Receptors, Chimeric Antigen
T cells
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
Treatment Outcome
Xenograft Model Antitumor Assays
Title The efficacy and safety of CAR-T cell therapy in patients with refractory ALL and concomitant HBV infection
URI https://link.springer.com/article/10.1038/s41375-020-0952-4
https://www.ncbi.nlm.nih.gov/pubmed/32632097
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Volume 34
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