Advanced human developmental toxicity and teratogenicity assessment using human organoid models

• Published in: Ecotoxicology and environmental safety Vol. 235; p. 113429
• Main Authors: Li, Minghui, Gong, Jing, Gao, Lixiong, Zou, Ting, Kang, Jiahui, Xu, Haiwei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.04.2022; Elsevier
• Subjects: Animals; Brain; Developmental toxicity; Human organoids; Humans; Kidney; Organoids - physiology; Stem cells; Teratogenicity; Developmental toxicity; Human organoids; Teratogenicity; Stem cells

Tremendous progress has been made in the field of toxicology leading to the advance of developmental toxicity assessment. Conventional animal models and in vitro two-dimensional models cannot accurately describe toxic effects and predict actual in vivo responses due to obvious inter-species differen...