Advanced human developmental toxicity and teratogenicity assessment using human organoid models

Tremendous progress has been made in the field of toxicology leading to the advance of developmental toxicity assessment. Conventional animal models and in vitro two-dimensional models cannot accurately describe toxic effects and predict actual in vivo responses due to obvious inter-species differen...

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Published inEcotoxicology and environmental safety Vol. 235; p. 113429
Main Authors Li, Minghui, Gong, Jing, Gao, Lixiong, Zou, Ting, Kang, Jiahui, Xu, Haiwei
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 15.04.2022
Elsevier
Subjects
Animals
Brain
Developmental toxicity
Human organoids
Humans
Kidney
Organoids - physiology
Stem cells
Teratogenicity
Developmental toxicity
Human organoids
Teratogenicity
Stem cells
Online AccessGet full text
ISSN0147-6513
1090-2414
1090-2414
DOI10.1016/j.ecoenv.2022.113429

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Abstract Tremendous progress has been made in the field of toxicology leading to the advance of developmental toxicity assessment. Conventional animal models and in vitro two-dimensional models cannot accurately describe toxic effects and predict actual in vivo responses due to obvious inter-species differences between humans and animals, as well as the lack of a physiologically relevant tissue microenvironment. Human embryonic stem cell (hESC)- and induced pluripotent stem cell (iPSC)-derived three-dimensional organoids are ideal complex and multicellular organotypic models, which are indispensable in recapitulating morphogenesis, cellular interactions, and molecular processes of early human organ development. Recently, human organoids have been used for drug discovery, chemical toxicity and safety in vitro assessment. This review discusses the recent advances in the use of human organoid models, (i.e., brain, retinal, cardiac, liver, kidney, lung, and intestinal organoid models) for developmental toxicity and teratogenicity assessment of distinct tissues/organs following exposure to pharmaceutical compounds, heavy metals, persistent organic pollutants, nanomaterials, and ambient air pollutants. Combining next-generation organoid models with innovative engineering technologies generates novel and powerful tools for developmental toxicity and teratogenicity assessment, and the rapid progress in this field is expected to continue. •Advances in stem cell techniques for toxicity assessment.•Human organoids can decipher the embryonic development and morphogenesis.•Organoid technologies for developmental toxicology assessment.•Advanced next-generation human organoids toward next-level toxicity testing.
AbstractList Tremendous progress has been made in the field of toxicology leading to the advance of developmental toxicity assessment. Conventional animal models and in vitro two-dimensional models cannot accurately describe toxic effects and predict actual in vivo responses due to obvious inter-species differences between humans and animals, as well as the lack of a physiologically relevant tissue microenvironment. Human embryonic stem cell (hESC)- and induced pluripotent stem cell (iPSC)-derived three-dimensional organoids are ideal complex and multicellular organotypic models, which are indispensable in recapitulating morphogenesis, cellular interactions, and molecular processes of early human organ development. Recently, human organoids have been used for drug discovery, chemical toxicity and safety in vitro assessment. This review discusses the recent advances in the use of human organoid models, (i.e., brain, retinal, cardiac, liver, kidney, lung, and intestinal organoid models) for developmental toxicity and teratogenicity assessment of distinct tissues/organs following exposure to pharmaceutical compounds, heavy metals, persistent organic pollutants, nanomaterials, and ambient air pollutants. Combining next-generation organoid models with innovative engineering technologies generates novel and powerful tools for developmental toxicity and teratogenicity assessment, and the rapid progress in this field is expected to continue.
Tremendous progress has been made in the field of toxicology leading to the advance of developmental toxicity assessment. Conventional animal models and in vitro two-dimensional models cannot accurately describe toxic effects and predict actual in vivo responses due to obvious inter-species differences between humans and animals, as well as the lack of a physiologically relevant tissue microenvironment. Human embryonic stem cell (hESC)- and induced pluripotent stem cell (iPSC)-derived three-dimensional organoids are ideal complex and multicellular organotypic models, which are indispensable in recapitulating morphogenesis, cellular interactions, and molecular processes of early human organ development. Recently, human organoids have been used for drug discovery, chemical toxicity and safety in vitro assessment. This review discusses the recent advances in the use of human organoid models, (i.e., brain, retinal, cardiac, liver, kidney, lung, and intestinal organoid models) for developmental toxicity and teratogenicity assessment of distinct tissues/organs following exposure to pharmaceutical compounds, heavy metals, persistent organic pollutants, nanomaterials, and ambient air pollutants. Combining next-generation organoid models with innovative engineering technologies generates novel and powerful tools for developmental toxicity and teratogenicity assessment, and the rapid progress in this field is expected to continue.Tremendous progress has been made in the field of toxicology leading to the advance of developmental toxicity assessment. Conventional animal models and in vitro two-dimensional models cannot accurately describe toxic effects and predict actual in vivo responses due to obvious inter-species differences between humans and animals, as well as the lack of a physiologically relevant tissue microenvironment. Human embryonic stem cell (hESC)- and induced pluripotent stem cell (iPSC)-derived three-dimensional organoids are ideal complex and multicellular organotypic models, which are indispensable in recapitulating morphogenesis, cellular interactions, and molecular processes of early human organ development. Recently, human organoids have been used for drug discovery, chemical toxicity and safety in vitro assessment. This review discusses the recent advances in the use of human organoid models, (i.e., brain, retinal, cardiac, liver, kidney, lung, and intestinal organoid models) for developmental toxicity and teratogenicity assessment of distinct tissues/organs following exposure to pharmaceutical compounds, heavy metals, persistent organic pollutants, nanomaterials, and ambient air pollutants. Combining next-generation organoid models with innovative engineering technologies generates novel and powerful tools for developmental toxicity and teratogenicity assessment, and the rapid progress in this field is expected to continue.
Tremendous progress has been made in the field of toxicology leading to the advance of developmental toxicity assessment. Conventional animal models and in vitro two-dimensional models cannot accurately describe toxic effects and predict actual in vivo responses due to obvious inter-species differences between humans and animals, as well as the lack of a physiologically relevant tissue microenvironment. Human embryonic stem cell (hESC)- and induced pluripotent stem cell (iPSC)-derived three-dimensional organoids are ideal complex and multicellular organotypic models, which are indispensable in recapitulating morphogenesis, cellular interactions, and molecular processes of early human organ development. Recently, human organoids have been used for drug discovery, chemical toxicity and safety in vitro assessment. This review discusses the recent advances in the use of human organoid models, (i.e., brain, retinal, cardiac, liver, kidney, lung, and intestinal organoid models) for developmental toxicity and teratogenicity assessment of distinct tissues/organs following exposure to pharmaceutical compounds, heavy metals, persistent organic pollutants, nanomaterials, and ambient air pollutants. Combining next-generation organoid models with innovative engineering technologies generates novel and powerful tools for developmental toxicity and teratogenicity assessment, and the rapid progress in this field is expected to continue. •Advances in stem cell techniques for toxicity assessment.•Human organoids can decipher the embryonic development and morphogenesis.•Organoid technologies for developmental toxicology assessment.•Advanced next-generation human organoids toward next-level toxicity testing.
ArticleNumber 113429
Author Zou, Ting
Gao, Lixiong
Xu, Haiwei
Gong, Jing
Kang, Jiahui
Li, Minghui
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  surname: Gao
  fullname: Gao, Lixiong
  organization: Department of Ophthalmology, Third Medical Center of PLA General Hospital, Beijing 100039, China
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  givenname: Ting
  surname: Zou
  fullname: Zou, Ting
  organization: Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China
– sequence: 5
  givenname: Jiahui
  surname: Kang
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  organization: Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China
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  givenname: Haiwei
  surname: Xu
  fullname: Xu, Haiwei
  email: haiweixu2001@163.com
  organization: Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China
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ISSN 0147-6513
1090-2414
IngestDate Wed Aug 27 01:22:36 EDT 2025
Thu Jul 10 22:38:14 EDT 2025
Wed Feb 19 02:25:56 EST 2025
Thu Apr 24 22:54:38 EDT 2025
Tue Jul 01 04:00:33 EDT 2025
Fri Feb 23 02:39:29 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords Developmental toxicity
Human organoids
Teratogenicity
Stem cells
Language English
License This is an open access article under the CC BY license.
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
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PublicationTitle Ecotoxicology and environmental safety
PublicationTitleAlternate Ecotoxicol Environ Saf
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Snippet Tremendous progress has been made in the field of toxicology leading to the advance of developmental toxicity assessment. Conventional animal models and in...
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SubjectTerms Animals
Brain
Developmental toxicity
Human organoids
Humans
Kidney
Organoids - physiology
Stem cells
Teratogenicity
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Title Advanced human developmental toxicity and teratogenicity assessment using human organoid models
URI https://dx.doi.org/10.1016/j.ecoenv.2022.113429
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