Engineering macrophage-derived exosomes for targeted chemotherapy of triple-negative breast cancer

• Published in: Nanoscale Vol. 12; no. 19; pp. 1854 - 1862
• Main Authors: Li, Sha, Wu, Yijing, Ding, Fei, Yang, Jiapei, Li, Jing, Gao, Xihui, Zhang, Chuan, Feng, Jing
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 21.05.2020
• Subjects: Anticancer properties; Apoptosis; Biocompatibility; Blood circulation; Breast cancer; Cell Line, Tumor; Chemotherapy; Doxorubicin; Doxorubicin - pharmacology; Drug delivery systems; Exosomes; Glycolic acid; Humans; Immune system; In vivo methods and tests; Macrophages; Nanoparticles; Toxicity; Triple Negative Breast Neoplasms - drug therapy

Triple-negative breast cancer (TNBC) is the most metastatic and recurrent subtype of all breast cancers. Owing to the lack of therapeutic targets, chemotherapy and surgical intervention are the only treatments for TNBC. However, the effectiveness of chemotherapeutics is limited by its shortcomings s...