Benzamides Substituted with Quinoline-Linked 1,2,4-Oxadiazole: Synthesis, Biological Activity and Toxicity to Zebrafish Embryo

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 12; p. 3946
• Main Authors: Sun, Bin-Long, Wang, Ying-Ying, Yang, Sen, Tu, Min-Ting, Shao, Ying-Ying, Hua, Yi, Zhou, Yi, Tan, Cheng-Xia
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 20.06.2022; MDPI
• Subjects: 1,2,4-oxadiazole; Acids; Biological activity; By products; Cysts; Embryos; Mortality; Pesticides; quinoline; Spectrum analysis; synthesis; Toxicity

To develop new compounds with high activity, broad spectrum and low-toxicity, 17 benzamides substituted with quinoline-linked 1,2,4-oxadiazole were designed using the splicing principle of active substructures and were synthesized. The biological activities were evaluated against 10 fungi, indicatin...