The effect of the very low dosage diltiazem on tacrolimus exposure very early after kidney transplantation: a randomized controlled trial

• Published in: Scientific reports Vol. 12; no. 1; pp. 14247 - 11
• Main Authors: Susomboon, Teerada, Kunlamas, Yotsaya, Vadcharavivad, Somratai, Vongwiwatana, Attapong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.08.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/208; 692/308/575; 692/4022; Cytochrome P-450 CYP3A - genetics; Cytochrome P450; Diltiazem; Dosage; Genotype; Genotypes; Humanities and Social Sciences; Immunosuppressive agents; Immunosuppressive Agents - therapeutic use; Kidney Transplantation; Kidney transplants; multidisciplinary; Science; Science (multidisciplinary); Tacrolimus

The objective of this study was to assess the effect of the very low dosage of diltiazem on tacrolimus exposure during the first week post-kidney transplantation, among cytochrome P450 (CYP) 3A5 expressers who did not receive diltiazem (EXplb), CYP3A5 expressers who received the very low dose diltia...