Twenty-four–Month Outcomes of the Ranibizumab for Edema of the Macula in Diabetes – Protocol 3 with High Dose (READ-3) Study

• Published in: Ophthalmology (Rochester, Minn.) Vol. 123; no. 12; pp. 2581 - 2587
• Main Authors: Sepah, Yasir J., Sadiq, Mohammad Ali, Boyer, David, Callanan, David, Gallemore, Ron, Bennett, Michael, Marcus, Dennis, Halperin, Lawrence, Hassan, Muhammad, Campochiaro, Peter A., Nguyen, Quan Dong, Do, Diana V., Lit, Eugene, Kruger, Erik, Pollack, John, Halperin, Larry, Zhang, Kang, Symons, Andrew, Abraham, Prema, Callanan, David G., Conway, Brian P., Wilson, David J., Sepah, Yasir Jamal, Hanout, Mostafa, Agarwal, Aniruddha, Afridi, Rubbia, Greer, Lisa
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2016
• Subjects: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors - administration & dosage; Angiogenesis Inhibitors - adverse effects; Diabetic Retinopathy - drug therapy; Diabetic Retinopathy - physiopathology; Double-Blind Method; Female; Follow-Up Studies; Humans; Intravitreal Injections; Macula Lutea - drug effects; Macular Edema - drug therapy; Macular Edema - physiopathology; Male; Middle Aged; Ophthalmology; Ranibizumab - administration & dosage; Ranibizumab - adverse effects; Retreatment; Tomography, Optical Coherence; Treatment Outcome; Vascular Endothelial Growth Factor A - antagonists & inhibitors; Visual Acuity - drug effects; Visual Acuity - physiology; OCT; SD OCT; FDA; READ-3; ETDRS; VEGF; TD-OCT; RBZ; VA; PRN; CFT; BCVA; DME; optical coherence tomography; ranibizumab; pro re nata; Food and Drug Administration; diabetic macular edema; Ranibizumab for Edema of the mAcula in Diabetes – Protocol 3 with High Dose; visual acuity; spectral-domain optical coherence tomography; central foveal thickness; time-domain optical coherence tomography; Early Treatment Diabetic Retinopathy Study; vascular endothelial growth factor; best-corrected visual acuity

To compare 2.0 mg ranibizumab (RBZ) injections with 0.5 mg RBZ for eyes with center-involved diabetic macular edema (DME). Randomized, controlled, double-masked (to the dose), interventional, multicenter clinical trial. A total of 152 patients (152 eyes) with DME. Eligible eyes were randomized in a...