Enhancement of tumor cell death by combining cisplatin with an oncolytic adenovirus carrying MDA-7/IL-24

• Published in: Acta pharmacologica Sinica Vol. 30; no. 4; pp. 467 - 477
• Main Authors: Wu, Yu-mei, Zhang, Kang-jian, Yue, Xue-tian, Wang, Yi-qiang, Yang, Yi, Li, Gong-chu, Li, Na, Wang, Yi-gang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2009; Nature Publishing Group
• Subjects: Adenoviridae - genetics; Antineoplastic Agents - pharmacology; Apoptosis; Biomedical and Life Sciences; Biomedicine; Cell death; Cell Line; Cisplatin - pharmacology; Combined Modality Therapy; Dose-Response Relationship, Drug; Genetic Therapy; Humans; Immunology; Interleukins - genetics; Internal Medicine; MDA-7/IL-24; Medical Microbiology; Neoplasms - pathology; Neoplasms - therapy; Oncolytic Virotherapy; Original; original-article; Pharmacology/Toxicology; Vaccine; 流式细胞仪分析; 溶瘤腺病毒; 白细胞介素24; 肿瘤细胞死亡; 腺病毒携带; 诱导凋亡作用; apoptosis; MDA-7/IL-24; oncolytic adenovirus; cisplatin

Aim： The aim of this study was to creatively implement a novel chemo-gene-virotherapeutic strategy and further strengthen the antitumor effect in cancer cells by the combined use of ZD55-IL-24 and cisplafin. Methods： ZD55-IL-24 is an oncolytic adenovirus that harbors interleukin 24 （IL-24）, which ha...