Effects of methotrexate on the viscoelastic properties of single cells probed by atomic force microscopy

• Published in: Journal of biological physics Vol. 42; no. 4; pp. 551 - 569
• Main Authors: Li, Mi, Liu, Lianqing, Xiao, Xiubin, Xi, Ning, Wang, Yuechao
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.10.2016; Springer Nature B.V
• Subjects: Animals; Atomic physics; Biochemistry; Biological and Medical Physics; Biophysics; Cell Line; Cells; Complex Fluids and Microfluidics; Complex Systems; Elastic Modulus - drug effects; Humans; Methotrexate - pharmacology; Mice; Microscopy; Microscopy, Atomic Force; Neurosciences; Original Paper; Physics; Physics and Astronomy; Single-Cell Analysis; Soft and Granular Matter; Viscoelasticity; Viscosity - drug effects; Young’s modulus; Atomic force microscopy; Viscoelastic properties; Methotrexate; Cell; Relaxation time

Methotrexate is a commonly used anti-cancer chemotherapy drug. Cellular mechanical properties are fundamental parameters that reflect the physiological state of a cell. However, so far the role of cellular mechanical properties in the actions of methotrexate is still unclear. In recent years, probin...