A novel mutation in the TUBB8 gene is associated with complete cleavage failure in fertilized eggs

• Published in: Journal of assisted reproduction and genetics Vol. 35; no. 7; pp. 1349 - 1356
• Main Authors: Yuan, Ping, Zheng, Lingyan, Liang, Hao, Li, Yu, Zhao, Haijing, Li, Ruiqi, Lai, Luhua, Zhang, Qingxue, Wang, Wenjun
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2018; Springer Nature B.V
• Subjects: Adult; Bioinformatics; China; Cleavage Stage, Ovum - physiology; Eggs; Embryogenesis; Embryonic Development - physiology; Female; Fertilization in Vitro - methods; Genetics; Genotypes; Glutamic acid; Gynecology; Human Genetics; Humans; In vitro fertilization; Infertility; Infertility, Female - genetics; Lysine; Medicine; Medicine & Public Health; Mutation; Mutation - genetics; Oocytes; Oocytes - physiology; Phenotypes; Reproductive Medicine; Tubulin; Tubulin - genetics; Zygote - physiology; 2PN arrest; Cleavage failure; Mutation; Infertility; TUBB8

Purpose Cleavage of the zygote during human reproduction is a key event of early embryonic development. The genetic events associated with idiopathic embryonic cleavage failure are not certain. Mutations in the tubulin beta 8 class VIII ( TUBB8 ) gene have been reported to be associated with oocyte...