The m6A demethylase ALKBH5-mediated upregulation of DDIT4-AS1 maintains pancreatic cancer stemness and suppresses chemosensitivity by activating the mTOR pathway - Zhang, Yi; Liu, Xiaomeng; Wang, Yan; Lai, Shihui; Wang, Zhiqian; Yang, Yudie; Liu, Wenhui; Wang, Hongquan; Tang, Bo (Molecular cancer, 2022)
Keywords: ALKBH5; Animal models; Antibodies; Binding sites; Bioinformatics; Cancer; Care and treatment; Chemoresistance; Chemosensitivity; Chemotherapy; DDIT4-AS1; DNA damage; Drug resistance; Flow cytometry; Gemcitabine; Growth factors; HuR protein; Hypoxia; Immunoprecipitation; Medical prognosis; Methyltransferases; Molecular modelling; mRNA stability; N6-methyladenosine; Pancreatic cancer; Patients; Phosphorylation; Prognosis; Proteins; RNA; RNA sequencing; Scientific equipment and supplies industry; Stemness; TOR protein; Tumors; UPF1; Xenografts; United States; China; Grand Island New York; St Louis Missouri; United States--US; Germany