Intravenous formulation of Panax notoginseng root extract: human pharmacokinetics of ginsenosides and potential for perpetrating drug interactions - Pintusophon, Salisa; Niu, Wei; Duan, Xiao-na; Olaleye, Olajide E; Huang, Yu-hong; Wang, Feng-qing; Li, Yan-fen; Yang, Jun-ling; Li, Chuan (Acta pharmacologica Sinica, 2019)
Keywords: Administration, Intravenous; Adult; Biomedical and Life Sciences; Biomedicine; Cerebrovascular diseases; Chromatography, Liquid; Coronary artery disease; Cryopreservation; Cytochrome P-450 CYP3A - biosynthesis; Cytochrome P450; Dosage; Drug Compounding; Drug dosages; Drug interaction; Drug Interactions; Drugs, Chinese Herbal - administration & dosage; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - pharmacokinetics; Female; Ginsenosides; Ginsenosides - administration & dosage; Ginsenosides - chemistry; Ginsenosides - pharmacokinetics; Healthy Volunteers; Heart diseases; Hepatocytes; Hepatocytes - drug effects; Hepatocytes - metabolism; Human subjects; Humans; Immunology; Internal Medicine; Intravenous administration; Ischemia; Liquid chromatography; Liver-Specific Organic Anion Transporter 1 - antagonists & inhibitors; Liver-Specific Organic Anion Transporter 1 - metabolism; Male; Mass Spectrometry; Mass spectroscopy; Medical Microbiology; Midazolam; Molecular Conformation; Organic anion transporting polypeptide; Panax notoginseng; Pharmacokinetics; Pharmacology/Toxicology; Plant Roots - chemistry; Vaccine; Vascular diseases; Young Adult; ginsenoside; herbal medicine–drug interactions; organic anion-transporting polypeptide 1B3; cytochrome P450 3A; XueShuanTong; Panax notoginseng