Postmortem transcriptional profiling reveals widespread increase in inflammation in schizophrenia: a comparison of prefrontal cortex, striatum, and hippocampus among matched tetrads of controls with subjects diagnosed with schizophrenia, bipolar or major depressive disorder

• Published in: Translational psychiatry Vol. 9; no. 1; p. 151
• Main Authors: Lanz, Thomas A., Reinhart, Veronica, Sheehan, Mark J., Rizzo, Stacey J. Sukoff, Bove, Susan E., James, Larry C., Volfson, Dmitri, Lewis, David A., Kleiman, Robin J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.05.2019; Nature Publishing Group
• Subjects: 38/39; 38/61; 631/378/340; 692/699/476/1799; Animals; Antipsychotics; Autopsy; Behavioral Sciences; Biological Psychology; Bipolar disorder; Bipolar Disorder - genetics; Bipolar Disorder - immunology; Bipolar Disorder - metabolism; Brain; Corpus Striatum - immunology; Corpus Striatum - metabolism; Depressive Disorder, Major - genetics; Depressive Disorder, Major - immunology; Depressive Disorder, Major - metabolism; Gene Expression Profiling; Hippocampus - immunology; Hippocampus - metabolism; Humans; Inflammation; Inflammation - genetics; Inflammation - immunology; Inflammation - metabolism; Male; Medicine; Medicine & Public Health; Mental depression; Mental disorders; Neurosciences; Pharmacotherapy; Prefrontal Cortex - immunology; Prefrontal Cortex - metabolism; Psychiatry; Psychotropic drugs; Rats; Rats, Sprague-Dawley; Schizophrenia; Schizophrenia - genetics; Schizophrenia - immunology; Schizophrenia - metabolism

Psychiatric disorders such as schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD) arise from complex interactions between genetic and environmental factors. Common genetic variants associated with multiple psychiatric disorders suggest that shared genetic architecture cou...